Results 131 to 140 of about 1,982,798 (318)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
THIRTY-SIXTH ANNUAL REPORT OF THE Department of Social Services OF THE STATE OF SOUTH CAROLINA FOR THE YEAR ENDED JUNE 30, 1973 Volume I [PDF]
, 1973 Each year the South Carolina Department of Social Services produces an annual accountability report for the South Carolina General Assembly and the Budget and Control Board.
South Carolina Department of Social Services
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Sociologies, 2019 The non-take-up of social rights has been analysed from different perspectives. These open up methodological, conceptual and epistemological questions.
Frédérique Leresche
doaj
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
THIRTY-SEVENTH ANNUAL REPORT OF THE Department of Social Services OF THE STATE OF SOUTH CAROLINA FOR THE YEAR ENDED JUNE 30, 1974 [PDF]
, 1974 Each year the South Carolina Department of Social Services produces an annual accountability report for the South Carolina General Assembly and the Budget and Control Board.
South Carolina Department of Social Services
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
, 1938 February, 1938. This report, prepared in collaboration with the Division of Research and Statistics of the State Board of Social Welfare, attempts to present the best possible basic estimate of social welfare costs in 1938--Foreword.SUMMARY I.
Kansas. Legislature. Legislative Council. Research Department.
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