Results 91 to 100 of about 16,474,381 (266)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Why Don’t They Leave? Reasons for the Immobility of Young Adults Remaining in Villages in Deprived Areas

open access: yesEuropean Countryside
The reasons for immobility in a rural space are not self-evident in previous literature and research. Through our qualitative research, we aim to contribute to explanations for staying in less-favoured rural areas, by taking into account indicators such ...
Czibere Ibolya, Lonczák Noémi
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Social Status in Norway and the Law of Jante: An Analysis of ISSP Social Inequality Data [PDF]

open access: yesEuropean Journal of Interdisciplinary Studies, 2016
This study examines International Social Survey Programme data from the 1999 social inequality module for evidence of Janteloven (‘the law of Jante’) in Norway – a widely known though often disputed description for aspects of Norwegian (and Scandinavian)
Daniel R. PALAMARA
doaj  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Brief to Ont. Ministry of Community and Social Services

open access: yes
The Ontario Committee on the Status of Women, a grassroots feminist group, was established in 1970. Its purpose was to seek implementation in Ontario of the Recommendations of the Royal Commission on the Status of ...
Ontario Committee on the Status of Women
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Human rights and critical social work: competing epistemologies for practice

open access: yes, 2016
The paper argues that the idea of human rights remains a 'two-edged sword' for critical social work practice. On one hand, human rights implies a progressive stance for critical social workers.
Ife, Jim   +4 more
core  

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