Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Effects of Physical Activity, Metabolic Syndrome, and Social Status on ECG Parameters in Children: A Prospective Cohort Study. [PDF]
J Cardiovasc Dev DisKézdi Á +8 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Higher self-assessed subjective social status is associated with worse perception of others' emotions. [PDF]
Sci RepLee VK, Khaw MW, Kranton RE, Huettel SA.
europepmc +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
, 2019 Competition involves two main dimensions, a rivalry for resources and the ranking of relative performance. If socially recognized, the latter yields a ranking in terms of social status. The rivalry for resources resulting from competitive incentives has been found to negatively affect women's performance relative to that of men.
Schram, Arthur +2 more
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Rapid Changes in Cholinergic Signaling, Myelination, and Thyroid Signaling Pathway Gene Expression in Amygdala Subnuclei in Response to Social Status Maintenance and Reorganization. [PDF]
Eur J NeurosciMilewski TM, Lee W, Rada KR, Curley JP.
europepmc +1 more source
Examining individual social status using the MacArthur Scale of Subjective Social Status: Findings from the Born in Bradford study. [PDF]
SSM Popul Health, 2023 Moss RH, Kelly B, Bird PK, Pickett KE.
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Deep learning reveals that multidimensional social status drives population variation in 11,875 US participant cohort. [PDF]
PLoS OneMarotta J +7 more
europepmc +1 more source