Results 61 to 70 of about 62,974 (251)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Resilience and risk perception in water scarcity: an analysis from Bourdieu's theory

Frontiers in Water
IntroductionWater scarcity is as much a social challenge as it is a climate-driven problem, yet the role of social inequality in shaping adaptive behavior remains underexplored.
Cándida Angelina Soler-Vargas, Miguel A. De-Luque-Villa, Claudia Patricia Gómez-Rendón   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Habilidades cognitivas: transmisión intergeneracional por niveles socioeconómicos

Estudios Económicos, 2008
Using the ENNViH 2002 survey, a switching model shows that signifi- cant differences exist in the formation of infant cognitive ability across Mexican social strata.
David Mayer Foulkes, María Fernanda López Olivo, Edson Serván Mori   +2 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Adiposidad y patrón de grasa en jóvenes venezolanos por estrato social

Archivos Latinoamericanos de Nutrición
La adiposidad y el patrón de grasa son indicadores de riesgo importantes en la identificación temprana de las enfermedades crónicas. Ambos se exploraron en 836 jóvenes de 11, 13 y 15 años del Estudio Condiciones de Vida, Fundacredesa 1996.
Maritza Landaeta- Jiménez, Betty M Pérez, Ynay Escalante   +2 more
doaj  

Assessment of social isolation and changes in Parkinson’s disease symptoms during the COVID-19 pandemic: A longitudinal study

Clinical Parkinsonism & Related Disorders
Background: COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson’s disease. Objective: This study aimed to explore changes in social isolation and their associations with PD symptoms using ...
Anish Mehta, Samuel Y.E. Ng, Shermyn X.M. Neo, Nicole S.Y. Chia, Ehsan S. Saffari, Thyagarajan Shivashanmugam, Xinyi Choi, Dede L. Heng, Z.Y. Xu, K.Y. Tay, W.L. Au, E.K. Tan, Louis C.S. Tan   +12 more
doaj   +1 more source

Social Inequality in Every Day Laughing Discourse of Modern Russia

Vestnik MGIMO-Universiteta, 2012
This article deals with the everyday discourse of the social inequality. The author analyses the ways in which humor is used to interpritate the social inequalities and the emergence of new privileged strata.
N. N. Zarubina
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source