Results 71 to 80 of about 412,898 (292)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

"Stratification and Mortality - A Comparison of Education, Class, Status and Income" [PDF]

In many analyses of social inequality in health, different dimensions of social stratification have been used more or less interchangeably as measures of the individual’s general social standing.
Erikson, Robert, Torssander, Jenny
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Linguistic Means of Reflecting Social Differences in British Press

Vestnik MGIMO-Universiteta, 2012
The article deals with the main tendencies of modern British newspaper language addressed to readers with different background. Comparing texts in «quality» newspapers and «middlebrow» tabloids allows to reveal linguistic means differing according to ...
V. V. Ignatenko
doaj   +1 more source

Social stratification and out-of-school learning [PDF]

, 2009
To study effects of out-of-school learning we use data on boarding home pupils who attended elementary public schools in the 1940's. The out-of-school environment at the boarding homes could be considered being more learner friendly than the home ...
Andersson, Christian, Johansson, Per
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Access and stratification in Nordic higher education. A review of cross-cutting research themes and issues*

Education Inquiry, 2018
The purpose of this review is to investigate cross-cutting research themes and issues related to access and stratification in Nordic higher education (H.E.) (Denmark, Iceland, Finland, Norway and Sweden). We synthesise how recent changes in H.E.
Ulpukka Isopahkala-Bouret, Mikael Börjesson, Dennis Beach, Nina Haltia, Jón Torfi Jónasson, Annukka Jauhiainen, Arto Jauhiainen, Sonja Kosunen, Hanna Nori, Agnete Vabø   +9 more
doaj   +1 more source

A duplication of marriages? An ethnographic account and assessment of the necessity for both traditional and Christian marriages for African Christians [PDF]

Pharos Journal of Theology
This article is based on ethnographic research for a doctoral study that was conducted in 2016 among the Ndau people of Chimanimani, Zimbabwe. The article described and assessed the practice of some African Christian churches, especially missionary ...
Elijah Elijah Ngoweni Dube
doaj   +1 more source

Understanding the Socio-Economic Distribution and Consequences of Patterns of Multiple Deprivation: An Application of Self-Organising Maps. ESRI WP302. June 2009 [PDF]

, 2009
In this paper we apply self organising maps (SOM) to a detailed set of material deprivation indicators from the Irish component of European Union Community Statistics on Income and Living Conditions (EU-SILC). The first stage of our analysis involves the
Lucchini, Mario, Maitre, Bertrand, Pisati, Maurizio, Whelan, Christopher T.   +3 more
core