Results 131 to 140 of about 3,047,023 (311)
El recuerdo del “mal”: Historizar la memoria
El Ágora USB, 2015 El presente texto aborda la pregunta: ¿Cómo avanzar en el conocimiento del pasado reciente desde la perspectiva de los sujetos?, ello presenta un desafío epistémico-metodológico que supone abordar las formas de razonamiento capaces de involucrar al ...
María Beatriz Gentile
doaj
Damaging the perfect image of athletes: How sport promotes envy [PDF]
We explore the behavioural and affective differences between subjects practicing sport activities and subjects not practicing sport. Are athletes more distressed by unfavourable social comparisons and more prone to engage in hostile behaviour than non ...
Jérémy CELSE
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Civitas - Revista de Ciências Sociais, 2009 This article argues that the study of the expansion of the normative ideal of law in our region must go beyond legal and institutional perspective to put the focus on relationships between individuals and the rule that are specific to each society.
Araujo, Kathya
doaj
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The endogenous nature of social preferences [PDF]
This paper presents evidence which challenges the view that techniques which are designed to measure the social preferences of subjects can always be accomplished in a nonintrusive manner.
Smith, John
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Ethical Problems in Evaluation Research [PDF]
, 1981 For some time, social scientists have been concerned with ethics in research. Much of what they have written has focused on research in general, but many of the points they raise are applicable to evaluation research in particular.
Johnson, Elisabeth J.
core +1 more source
Social infrastructure, social cohesion and subjective wellbeing
Wellbeing, Space and SocietyNeighborhood physical places that bring people together, referred to as social infrastructure, form the foundation of communities. Studies suggest that by facilitating social encounters, social infrastructure can enhance sense of social cohesion and belonging and may also improve subjective wellbeing.
openaire +2 more sources