Results 141 to 150 of about 15,500,895 (356)
Ethical implications of onto-epistemological pluralism in relation to entropy, [PDF]
, 2019 From the epistemological posture that we present in this work we sustain the following thesis:-That as subjects we constitute the world we live in through one of the possible conceptual frameworks.-Our cognitive and social practices construct the world ...
Gómez, Mónica
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
El recuerdo del “mal”: Historizar la memoria
El Ágora USB, 2015 El presente texto aborda la pregunta: ¿Cómo avanzar en el conocimiento del pasado reciente desde la perspectiva de los sujetos?, ello presenta un desafío epistémico-metodológico que supone abordar las formas de razonamiento capaces de involucrar al ...
María Beatriz Gentile
doaj
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Civitas - Revista de Ciências Sociais, 2009 This article argues that the study of the expansion of the normative ideal of law in our region must go beyond legal and institutional perspective to put the focus on relationships between individuals and the rule that are specific to each society.
Araujo, Kathya
doaj
Ethical Problems in Evaluation Research [PDF]
, 1981 For some time, social scientists have been concerned with ethics in research. Much of what they have written has focused on research in general, but many of the points they raise are applicable to evaluation research in particular.
Johnson, Elisabeth J.
core +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Music and dance as a coalition signaling system [PDF]
, 2002 Evidence suggests that humans have neurological specializations for music processing, but a compelling adaptationist account of music and dance is lacking.
Bryant, Gregory A, Hagen, Edward H
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source