Results 91 to 100 of about 1,952,808 (301)

Co-presence Communities: Using pervasive computing to support weak social networks

, 2006
Although the strongest social relationships feature most prominently in our lives, we also maintain a multitude of much weaker connections: the distant colleagues that we share a coffee with in the afternoon; the waitress at a our regular sandwich bar ...
De Roure, David, Lawrence, Jamie, Payne, Terry R.   +2 more
core  

Social media and student lifecycle: impact on career success [PDF]

, 2010
Over the past few years online social networks have become one of the most popular applications on the Internet. Naturally, social media is attracting a significant attention from researchers probing its educational applicability.
Benson, Vladlena, Filippaios, Fragkiskos, Morgan, Stephanie   +2 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Social support and reference group: the dual action mechanism of the social network on subjective poverty

Humanities & Social Sciences Communications
The social network is an important way to promote subjective poverty alleviation. Based on China Labor Dynamics Survey (CLDS) data from 2014, 2016, and 2018, this paper analyzes the action mechanism of social networks on the subjective poverty of Chinese
Suxia Li, Meng Cai
doaj   +1 more source

Suppressing epidemic spreading in multiplex networks with social-support

New Journal of Physics, 2018
Although suppressing the spread of a disease is usually achieved by investing in public resources, in the real world only a small percentage of the population have access to government assistance when there is an outbreak, and most must rely on resources
Xiaolong Chen, Ruijie Wang, Ming Tang, Shimin Cai, H Eugene Stanley, Lidia A Braunstein   +5 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A qualitative exploration of social support during treatment for severe alcohol use disorder and recovery

Addictive Behaviors Reports, 2017
Introduction: Severe alcohol use disorder (AUD) affects multiple aspects of an individual's life as well as their loved ones' lives. Perceived social support has the potential to help or hinder recovery efforts.
Alyssa T. Brooks, Miriam Magaña Lòpez, Alexandra Ranucci, Michael Krumlauf, Gwenyth R. Wallen   +4 more
doaj   +1 more source

Social support network and received support at stressful events

Advances in Methodology and Statistics, 2009
Many studies in the field of social support (e.g., Hobfoll, 1985; Thoits, 1985; Cutrona and Russell, 1990; Kienan, 1997) show that the effectiveness of a certain type of provided support and mechanisms by which the support works are often highly dependent on a specific situation, where support is needed.
Hlebec, Valentina, Kogovšek, Tina, Mrzel, Maja   +2 more
openaire   +4 more sources