Results 121 to 130 of about 4,923,465 (296)

Trust in the Justice System: Internet Survey after Introducing Mixed Tribunal System in Japan

open access: yesOñati Socio-Legal Series, 2015
People obey the law because they think it is legitimate, and trust is the key that makes the legal system work. The jury system promotes public trust in the justice system through lay people’s participation.
Masahiro Fujita   +2 more
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The Demographics of Social Media Users - 2012 [PDF]

open access: yes, 2013
A late 2012 survey by the Pew Research Center's Internet & American Life Project shows that young adults are more likely than others to use major social media. At the same time, other groups are interested in different sites and services.
Joanna Brenner, Maeve Duggan
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Are we measuring what we want to measure? [PDF]

open access: yes
The social context of survey interviews is likely to be important in survey measurement in developing countries, where respondents expect to benefit from participation.
FFF1Simona NNN1Bignami-Van Assche
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Who are those Green Guys? Understanding Online Activism in Chile from a Communicational Perspective

open access: yesPalabra Clave, 2013
DOI: 10.5294/pacla.2013.16.3.3 The primary objective of this study is to understand how activists in Chile are using the Internet and social media to learn about large-scale environmental projects and to make their voices heard in this new scenario via
Daniel Halpern   +2 more
doaj  

Retrospective database study of druggable mutation detection among patients with non-small cell lung cancer in Japan

open access: yesScientific Reports
Generally, non-small cell lung cancer (NSCLC) accounts for 90% of lung cancer cases in Japan. The detection of druggable mutations is necessary for selecting the appropriate systemic therapy for patients with NSCLC.
Yuya Yokochi   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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