Results 121 to 130 of about 1,503,791 (308)
Trees, Forests and PeopleAround the world, restoration activities are underway to halt and reverse ecosystem degradation. A key challenge is to identify restoration approaches that work for both people and nature – i.e.
Tom Reckmann +5 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
An assessment tool and integrated index for sustainable oil palm production [PDF]
, 2010 Many prominent sectors of the international agricultural commodities market have been calling upon their stakeholders to define and implement social responsibility and sustainability benchmarks, aiming at product quality and production practices ...
Caliman, Jean-Pierre +2 more
core
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
An Application of Conjoint Analysis in Agricultural Sustainability Assessment [PDF]
Increasing public interest in the concept of sustainable agriculture has resulted in the development of a number of methods that could be used for the assessment of sustainability of various agricultural production systems.
Sydorovych, Olha, Wossink, Ada
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Public policies, environmental health, sustainability and social inclusion in developed countries [PDF]
, 2006 The paper discusses the range of public policies, concerned with environment health, sustainability and social inclusion, recently introduced by governments in developed ...
Lethbridge, Jane
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Sherlock in OSS: A Novel Approach of Content-Based Searching in Object Storage System
IEEE AccessCloud-based Object Storage Systems (OSS) are known for their scalability, durability, availability, and concurrency. However, there is a noticable vaccum in open-source OSS for a straightforward way for users and administrators to conduct data searches ...
Jannatun Noor +6 more
doaj +1 more source
Building climate resilience, social sustainability and equity in global fisheries. [PDF]
NPJ Ocean Sustain, 2023 Prellezo R +4 more
europepmc +1 more source