Results 81 to 90 of about 1,512,127 (308)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Teaching the YouTube generation: exploring the benefits of an interactive teaching approach in sustainable product design [PDF]

, 2014
This paper presents findings from a doctoral study, which investigated effective methods for teaching social sustainability within product design courses in British and Irish universities. Specifically exploring, how to foster a holistic understanding of
Watkins, MA
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Social Sustainability: A design research approach to sustainable development [PDF]

, 2011
While issues such as clean production and energy efficiency are still central in sustainable development discourse, attention is increasingly on patterns of consumption at multiple levels in society.
Gregory, Judith, Mazé, Ramia, Redström, Johan   +2 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

SUSTAINABLE AGRIBUSINESS: DEVELOPING LOCAL SOLUTIONS TO GLOBAL CHALLENGES IN THE REGIONAL AGRIBUSINESS SECTOR IN AUSTRALIA [PDF]

The competitiveness of the agribusiness sector is critical to the social and economic sustainability of regional Australia, where agribusiness is directly responsible for one in five jobs (DNRE, 2002).
Cary, John W., Coath, Emma, Hansford, Peter   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Toward a low-pesticide agriculture: bridging practice theory and social-psychological concepts to analyze farmers’ routines

Sustainability: Science, Practice, & Policy
Agricultural crop protection (CP) today is under pressure not the least because it strongly relies on pesticides that negatively affect the environment and human health.
Antonia Kaiser, Robin Samuel, Paul Burger   +2 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Strategies and challenges for green campuses

Frontiers in Sustainable Cities
The global environmental and ecological climate crisis necessitates urgent mitigation and adaptation measures, with Higher Education Institutions (HEIs) playing a crucial role in driving the transition toward a sustainable future. This paper examines the
Zohar Barnett-Itzhaki, Zohar Barnett-Itzhaki, Sigal Tifferet, Sigal Tifferet, Daniel Berkowic, Tamir Arviv, Tamir Arviv, Alon Daya, Alon Daya, Gal Hagit Carasso Romano, Adi Levi, Adi Levi   +11 more
doaj   +1 more source