Results 101 to 110 of about 6,467,899 (240)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

RETROSPECTIVE ANALYSIS OF THE LEADING IDEAS OF DEVELOPMENT OF SOCIAL AND PEDAGOGICAL SYSTEMS

open access: yesВестник Мининского университета, 2017
Article investigates development of system approach and formation of the theory of development of social and pedagogical systems. In work historical aspects of formation and development of system approach, basic laws and regularities of consideration and
E. P. Sedykh
doaj   +2 more sources

Social insurance – a social system

open access: yesScientific works "Adilet", 2020
The article discusses in detail the problems of the system of social justice. Three levels of the social protection system in the Republic of Kazakhstan are shown. The experience of using the compulsory social insurance system, which has been in effect in the Republic of Kazakhstan since 2005, has been studied.
openaire   +1 more source

A wireless, real-time, social music performance system for mobile phones [PDF]

open access: yes, 2010
The paper reports on the Cellmusic system: a real-time, wireless distributed composition and performance system designed for domestic mobile devices.
Dovey, Matthew, Gibson, Ian
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

SOCIAL ESSENCE AND SPECIFICS OF SCIENTIFIC PRODUCTION

open access: yesНаучный вестник МГТУ ГА, 2016
The article reveals social essence and structure of science, likewise specificity of scientific production as of universal social labor; an extensive system of scientific production is revealed.
A. N. Kochergin
doaj  

Emerging trends: Dialogues between environmental sustainability in the management of social innovation projects for a sustainable future

open access: yesCiencia y Sociedad
The management of social innovation projects and their relationship with sustainable development is a growing interest in the academic and professional spheres. This paper analyzes emerging trends at the intersection of environmental sustainability and
Carlos David Martíez Ramíez   +3 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

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