Results 131 to 140 of about 1,562,081 (266)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The journalistic understanding of science as process and social system: A qualitative exploration in the German science journalism community. [PDF]

Public Underst Sci
Kreutzer T, Domgörgen F, Kaldewey D, Berger P, Wormer H.   +4 more
europepmc   +1 more source

Modeling stochastic processes in disease spread across a heterogeneous social system. [PDF]

Proc Natl Acad Sci U S A, 2019
Kim M, Paini D, Jurdak R.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A Friendlier "Kinda" Social System: Male Kinda Baboons Invest in Long-Term Social Bonds With Females. [PDF]

Am J Biol Anthropol
Weyher AH, Katinta M, Mubemba B, Petersdorf M, Kamilar JM, Schneider-Crease IA, Chiou KL.   +6 more
europepmc   +1 more source

Ecology and social system of northern gibbons living in cold seasonal forests. [PDF]

Zool Res, 2018
Guan ZH, Ma CY, Fei HL, Huang B, Ning WH, Ni QY, Jiang XL, Fan PF.   +7 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Modeling opinion misperception and the emergence of silence in online social system. [PDF]

PLoS One
Vilone D, Polizzi E.
europepmc   +1 more source

Charting the neglected West: The social system of Guinea baboons. [PDF]

Am J Phys Anthropol, 2017
Fischer J, Kopp GH, Dal Pesco F, Goffe A, Hammerschmidt K, Kalbitzer U, Klapproth M, Maciej P, Ndao I, Patzelt A, Zinner D.   +10 more
europepmc   +1 more source

The City as a Social System [PDF]

Science, 1969
openaire   +2 more sources