Results 181 to 190 of about 6,467,899 (240)
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
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Archives of General Psychiatry, 1971
I have outlined the techniques of social systems assessment and intervention developed as a result of intervening directly in the problems of the immediate social environment of over 1,600 routine psychiatric patients. The techniques are based on an application of therapeutic community principles to real life settings outside the hospital.
openaire +2 more sources
I have outlined the techniques of social systems assessment and intervention developed as a result of intervening directly in the problems of the immediate social environment of over 1,600 routine psychiatric patients. The techniques are based on an application of therapeutic community principles to real life settings outside the hospital.
openaire +2 more sources
Mathematical Social Sciences, 1983
Abstract We argue that there are 4 basic solution concepts for 2 × 2 symmetric games and corresponding to these, 4 basic human interactions and 4 types of societies. We propose a model in which the type of interaction is predicted by independence, inequality of power, communication, and mutuality of interests.
Kim, Ki Hang, Roush, Fred W.
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Abstract We argue that there are 4 basic solution concepts for 2 × 2 symmetric games and corresponding to these, 4 basic human interactions and 4 types of societies. We propose a model in which the type of interaction is predicted by independence, inequality of power, communication, and mutuality of interests.
Kim, Ki Hang, Roush, Fred W.
openaire +1 more source
Social system needs assessment
Long Range Planning, 1978Abstract Needs assessment is an integral part of most comprehensive planning procedures. The needs assessment strategy presented in this article is appropriate for use when the problems and needs of social systems are to be considered. It is based on the logic of systems theory and especially on the concept of open systems and system networks.
R L, Morasky, D, Amick
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Nature Nanotechnology, 2020
In reviewing a recent book, Chris Toumey reflects on the impact that social networks can have on the development of a number of technologies.
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In reviewing a recent book, Chris Toumey reflects on the impact that social networks can have on the development of a number of technologies.
openaire +2 more sources