Results 61 to 70 of about 1,562,081 (266)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Key Concepts in Education: Critical Issues beyond Definition and Discursive Practices
Seminar.net, 2013 Along with the processes of digitization, medialization and the globalization of communications and lifeworlds, new topics, subject matters, conceptualizations and methods have been developed in educational research and practice. On the one hand, from a
Theo Hug
doaj
The Monetary Measurement of Flood Damage and the Valuation of the Proactive Policies in Sicily
Geosciences, 2018 Although floods, as well as other natural disasters, can be considered as relevant causes of intra-generational inequalities, frequent catastrophes and the resulting damage to the territory can be seen as a consequence of a generalized indifference about
Maria Rosa Trovato, Salvatore Giuffrida
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Matrix-graphic simulation of social network: ergodic properties
Sistemnì Doslìdženâ ta Informacìjnì TehnologìïWe propose mathematical tools for social network simulation to obtain sufficient conditions for network ergodicity, defined as the existence of a steady state as time approaches infinity.
Igor Spectorsky +2 more
doaj +1 more source
Maternal Ideology in an MTN® Advertisement: Analysing Socio-Semiotic Reality as a Campaign for Peace
Journal of Language and Education, 2017 It seemed that the issue of maternal ideology as a device to curb social menaces has not attracted scholars. Thus, the study examined the use of maternal ideology in mobile telephone network (MTN®) as a means of influencing recipients against vices ...
Taofeek Olaiwola Dalamu
doaj +1 more source
Social insurance – a social system
Scientific works "Adilet", 2020 The article discusses in detail the problems of the system of social justice. Three levels of the social protection system in the Republic of Kazakhstan are shown. The experience of using the compulsory social insurance system, which has been in effect in the Republic of Kazakhstan since 2005, has been studied.
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source