Results 81 to 90 of about 5,702,498 (304)
Measuring quality in social care services: theory and practice [PDF]
, 2010 Measuring and assessing service quality in the social care sector presents distinct challenges. The 'experience' good properties of social care, for instance, and the large influence played by subjective judgements about the quality of personal ...
Fernández, José-Luis, Malley, Juliette
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Politics and GovernanceOver the last few decades, growing public dissatisfaction with institutions of representative democracy has become unignorable. Similar problems affecting representative democracy occur within the policy process, as traditional top-down policymaking ...
Nemanja Anđelković, Tara Tepavac
doaj +1 more source
Economic theory and social justice [PDF]
Is justice individualistic or both individualistic andsocial? Opposite views on this question include von Hayek, who said that `social justice' was an oxymoron, and the late Holy Father who, in Sollicitudo Rei Socialis said that some socio-economic ...
Johnson, Joseph
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A well-ordered society with publicly acknowledged principles - a re-interpretation of Rawlsian social contract [PDF]
, 2010 John Rawls is arguably the most influential political philosopher of the twentieth century. In his most seminal books, A Theory of Justice (1971), Rawls claims that his aim is to ‘present a conception of justice which generalizes and carries to a higher ...
Wong, Baldwin
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Politics and GovernanceWhile existing research has increasingly emphasized the need to embed democratic innovations within formal political structures to ensure their sustainability, analytical frameworks are largely rooted in normative democratic theory and often lack tools ...
Gazela Pudar Drasko, Irena Fiket
doaj +1 more source
A world of their making: an evaluation of the constructivist critique in international relations [PDF]
, 2000 IR constructivism maintain that a proper understanding of the way subjects interact with the world and with each other alerts us to the fallacy of conventional IR theory. And yet, for a theory that is so obviously dependent upon a rigorous working of the
Palan, Ronen
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
APPLICATIONS OF SOCIAL CAPITAL THEORY [PDF]
Experiments and studies were conducted to investigate the role of social capital. Social capital (relationship to others) is a productive asset which is a substitute for and complement to other productive assets.
Robison, Lindon J., Schmid, A. Allan
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