Results 191 to 200 of about 9,848,100 (335)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Value-based health care frameworks for the health technology assessments of "omics" technologies: an international survey. [PDF]

Int J Technol Assess Health Care
Osti T, Taha A, Reviriego-Rodrigo E, Pastorino R, Boccia S, Gutierrez-Ibarluzea I.   +5 more
europepmc   +1 more source

Housing Insecurity and Threats of Utility Shut-Offs Among Cancer Survivors in the United States, BRFSS 2022-2023. [PDF]

Cancer Med
Nguyen TD, Eberth JM, Ezenwankwo E, Schwartz GL.   +3 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Now I feel like I'm going to get to it soon: a brief, scalable intervention for state procrastination. [PDF]

BMC Psychol
Garg A, Shelat S, Schooler JW.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Health-related quality of life of adult post COVID-19 condition patients three years after infection and patient characteristics associated with change over time: a longitudinal analysis from the CORFU study. [PDF]

Qual Life Res
Suazo Guevara MM, Waardenburg SF, Klein DO, Bonsel GJ, Birnie E, Wintjens MSJN, van Bussel BCT, van Santen S, Ghossein-Doha C, Warlé MC, Jacobs LMC, Hemmen B, Kietselaer BLJH, Jansen G, Heemskerk SCM, Haagsma JA, van Kuijk SMJ.   +16 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Quality of life for middle and older aged people with chronic conditions in primary care: a cross-sectional study. [PDF]

BMC Prim Care
George S, Block H, Freeman M, Stevens A, Nguyen S, Dymmott A, Dent E, Milte R.   +7 more
europepmc   +1 more source