Results 91 to 100 of about 1,898,171 (312)

Longevity

Journal of Practical Ethics
The value of a person’s life is not reducible to the satisfaction of one’s desires or interests, including the interest in living longer.  A person who takes pleasure in beach vacations each summer may look forward to another stay at the
Douglas MacLean
doaj   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Social Value at Universities: Policy and Practice Guidance [PDF]

Universities globally can be major hubs of social and economic activity which drive change in society. We know that they can create multiple and diverse routes into employment, can have significant purchasing power which can inform standards across ...
Stevens, M, Carline, L, Shore, A, Skritsovali, K, Tyreman, S, Sachikonye, C, Wall, T, Westcott, C, Harvey, R, Carpenter, B, Hindley, A, Brown, J, Parasram, I   +12 more
core  

The ark of shared value: Using shared value creation to increase corporate social responsibility investments

The Ark of Shared Value is a fundamental guide for those involved in designing and implementing sustainable business projects. The Ark is a one-page tool that is easy to use and presents the key elements of sustainable projects.
Saenz Acosta, Cesar Sandro
core   +1 more source

Using a Delphi Method in the Future of PR and Communication Global Study: South African Findings on Social Impact and PR Education

Communicare
Public relations in Africa and South Africa has evolved in accordance with its changing landscape.  The purpose of this article is to present the views of South African public relations educators and practitioners who participated in a global study ...
Dalien Rene Benecke, Padhma Moodley, Corne Meintjes, Lida Holtzhaisen, Anette Degenaar, Neil H Levy   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The social return on investment of physical activity and nutrition interventions—a scoping review

Frontiers in Sports and Active Living
IntroductionScarcity of resources and mounting pressures on health systems make it critical to evaluate new and existing public health interventions related to physical activity and nutrition.
Anna Stielke, Kathryn Ashton, Andrew Cotter-Roberts, Mariana Dyakova   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Botanic Garden Tourism, Social Value, Health, and Well-Being

Journal of Zoological and Botanical Gardens
Many botanic gardens are flourishing, and many others can learn from those leading the way; at the same time, all can form new allegiances informed by service research.
Nicholas Catahan, Michelle Hopwood, Piumie Suraweera   +2 more
doaj   +1 more source