Results 271 to 280 of about 19,273,452 (314)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The Role of Corporate Social Responsibility in Mediating the Relationship between Profitability and Company Size on Company Value: Empirical Evidence from the Sharia Banking Industry Sector in Indonesia

Tazida Berliana Elma, Liana Mangifera
openalex   +2 more sources

The Meaning of Social and Ethical Values in Consumer Decision-Making for Sustainable Products in Urban Markets

Anna M Ngabalin
openalex   +2 more sources

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Coronavirus (covid-19) and social value co-creation

International journal of sociology and social policy, 2020
PurposeSociety has changed forever as a result of coronavirus (covid-19) with the new normal referring to lifestyle changes including social distancing and working from home.
V. Ratten
semanticscholar   +1 more source

How to Create Social Value Through Digital Social Innovation? Unlocking the Potential of the Social Value Creation of Digital Start-Ups

Journal of Social Entrepreneurship, 2020
Considering digital start-ups as agents of social innovation, this study highlights the Potential for Social Value Frame (PSVF) method. The latter helps examine how projects inherently frame the social domain beyond ranking techniques, and measures their
J. Faludi
semanticscholar   +1 more source

The Nature of the Social Firm: Alternative Organizational Forms for Social Value Creation and Appropriation

, 2020
I assess how alternative organizational forms affect the ability of multiple actors to appropriate economic rents in activities expected to create social value—defined as broad social benefits to a...
S. Lazzarini
semanticscholar   +1 more source

Strategic Social Value Orientation and Sustainability Performance: A commensuration perspective

Organization Studies
Firms increasingly express the strategic importance of creating social value in addition to financial and market value in their communications to investors. Yet, it is unclear what a strategic orientation towards social value creation entails and whether
Marcelo F. de la Cruz Jara, Jelena Spanjol, Theresa Doppstadt   +2 more
semanticscholar   +1 more source