Results 181 to 190 of about 17,141,351 (300)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2016 One of the main goals on this document is for obtain a wise knowledge about the diverse impacts and support the decisions in the social politics; especially in the evaluation and assignation of resources to social invest in programs or units where counting with concepts and tools that let the measurement of social values, and their different dimensions.
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Northern Ireland European Values Survey, 1999
, 2001 copyright UK Data Service and data collection copyright owner.The European Values Study (EVS) and World Values Survey (WVS) series is designed to enable a cross-national, cross-cultural comparison of values and norms on a wide variety of topics and to ...
Sinnott, R., University College Dublin, Centre for European Economic and Public Affairs +2 more
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
THE CONSTITUTION AS A SOCIAL VALUE AND SOCIAL VALUES IN THE CONSTITUTION
Abstract Modern jurisprudence views the Constitution not merely as a legal act, but as a fundamental axiological system where human dignity is recognized as the source of the constitutional order and the supreme value. The core values of the Constitution are structured into four groups: anthropocentric, socio-economic, socio-political, and spiritual ...
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National Institute for Health and Care Excellence, social values and healthcare priority setting. [PDF]
J R Soc Med, 2019 Littlejohns P +18 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The Law and Social Values: Medical Uncertainty. [PDF]
Clin Orthop Relat Res, 2017 Teo WZ, Brenner LH, Bal BS.
europepmc +1 more source