Results 41 to 50 of about 9,229,872 (350)

When the Social Meets the Semantic: Social Semantic Web or Web 2.5

open access: yesFuture Internet, 2012
The social trend is progressively becoming the key feature of current Web understanding (Web 2.0). This trend appears irrepressible as millions of users, directly or indirectly connected through social networks, are able to share and exchange any kind of
Salvatore F. Pileggi   +2 more
doaj   +1 more source

Associations Among Web-Based Civic Engagement and Discrimination, Web-Based Social Support, and Mental Health and Substance Use Risk Among LGBT Youth: Cross-Sectional Survey Study

open access: yesJournal of Medical Internet Research, 2023
BackgroundSocial media use is ubiquitous among lesbian, gay, bisexual, and transgender or nonbinary (LGBT) adolescents. The time spent on LGBT sites and involvement in social justice–oriented web-based civic activities can ...
Xiangyu Tao, Celia Fisher
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Permuting Web and Social Graphs [PDF]

open access: yesInternet Mathematics, 2009
Abstract Since the first investigations on web-graph compression, it has been clear that the ordering of the nodes of a web graph has a fundamental influence on the compression rate (usually expressed as the number of bits per link). The authors of the LINK database [Randall et al.
P. Boldi, M. Santini, S. Vigna
openaire   +2 more sources

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

open access: yesFEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq   +3 more
wiley   +1 more source

Bridging the Open Web and APIs: Alternative Social Media Alongside the Corporate Web

open access: yesSocial Media + Society, 2022
Concentrations of power over the internet among a small number of corporate platforms have motivated attempts to build alternative social media. Using the contemporary internet routinely involves relying on a small number of dominant corporate platforms.
Jack Jamieson   +2 more
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

open access: yesFEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman   +4 more
wiley   +1 more source

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