Results 41 to 50 of about 467,479 (315)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Le Facebook des étudiants marocains. Territoire relationnel et territoire des possibles
Revue Européenne des Migrations Internationales, 2014 This article questions the place of web practices in social networks of Moroccan students, the structuring and organization of these networks and how they fit into the space. The objective is to move the issue of international student mobility in linking
Sabrina Marchandise
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Tareas 2.0: la dimensión digital en el aula de español lengua extranjera [PDF]
marcoELE. Revista de Didáctica Español Lengua Extranjera, 2009 En este artículo los autores han buscado establecer una comparativa entre las características básicas de las nuevas aplicaciones de la web social y el proceso de enseñanza y aprendizaje de una segunda lengua, haciendo especial hincapié en las actitudes y
Herrera, Francisco, Conejo, Emilia
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
New perspectives on Web search engine research [PDF]
, 2012 Purpose–The purpose of this chapter is to give an overview of the context of Web search and search engine-related research, as well as to introduce the reader to the sections and chapters of the book.
Lewandowski, Dirk
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Challenging social media analytics: Web Science perspectives
, 2014 In this paper we outline some of the challenges for social media analytics and -- at the same time - challenge existing approaches to social media analysis.
Pope, Catherine J +10 more
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Googling social interactions: web search engine based social network construction. [PDF]
PLoS ONE, 2010 Social network analysis has long been an untiring topic of sociology. However, until the era of information technology, the availability of data, mainly collected by the traditional method of personal survey, was highly limited and prevented large-scale ...
Sang Hoon Lee +3 more
doaj +1 more source
Folksonomies, the semantic web, and movie recommendation [PDF]
, 2007 While the Semantic Web has evolved to support the meaningful exchange ofheterogeneous data through shared and controlled conceptualisations, Web 2.0 has demonstrated that large-scale community tagging sites can enrich the semantic web with readily ...
C. CATTUTO +13 more
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