Results 41 to 50 of about 1,851,219 (356)

Adaptive Maximization of Social Welfare

SSRN Electronic Journal
We consider the problem of repeatedly choosing policies to maximize social welfare. Welfare is a weighted sum of private utility and public revenue. Earlier outcomes inform later policies. Utility is not observed, but indirectly inferred. Response functions are learned through experimentation.
Nicol`o Cesa-Bianchi, Roberto Colomboni, Maximilian Kasy, Carolyn Fisher   +3 more
openaire   +5 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Food Insecurity among Elderly in Tehran: Prevalence, Risk and Protective Factors

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: Food insecurity is a major public health problem, especially among older adults living in developing countries. The present study aimed at examining the prevalence, and risk and protective factors for severe food insecurity among ...
Mina Eghrari, Maryam Sharifian Sani, Seyed Hossein Mohaqeqi Kamal, Gholamreza Ghaedamini Harouni, Nasibeh Zanjari, Sina Ahmadi   +5 more
doaj  

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Acceptance of Information and Communication Technology by the Elderly People Living in Tehran

Sālmand, 2019
Objectives Nowadays, Information and Communication Technology (ICT) provides a potential opportunity for communities by changing the concept of distance.
Mehdi Basakha, Seyed Hossein Mohaqeqi Kamal, Hakimeh Pashazadeh   +2 more
doaj  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Designing and Validation of a Living Standards Questionnaire in Tehran’s Elderly Community

Sālmand, 2019
Objectives Considering the importance of assessing living standards in society, the present study aimed to design a living standards questionnaire.
Mina Jahanpour, Seyed Hossein Mohaqeqi Kamal, Samaneh Hosseinzadeh, Homeira Sajjadi, Mehdi Basakha   +4 more
doaj  

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Motor Performance in Relation with Sustained Attention in Children with Attention Deficit Hyperactivity Disorder

Journal of Rehabilitation, 2012
Objective: Present study compares relationship between motor performance, sustained attention and impulse control in children with Attention Deficit Hyperactivity Disorder and normal children.
Solmaz Solouki, Fatemeh Behnia, Katayoun Khoushabi, Ebrahim Pishyareh, Samaneh Hossein-Zadeh   +4 more
doaj