Results 121 to 130 of about 1,195,997 (308)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Institution Formation in Public Goods Games [PDF]
Centralized sanctioning institutions are of utmost importance for overcoming free-riding tendencies and enforcing outcomes that maximize group welfare in social dilemma situations. However, little is known about how such institutions come into existence.
Kosfeld, Michael +2 more
core +4 more sources
Abstract Investing in public infrastructure is an important way to improve regional social welfare, and its effects on social welfare vary spatially across regions. Based on data from 33 counties (cities, districts) in China from 2005 to 2019, this paper employed SDM(spatial durbin model) to analyze the impact of public infrastructure on ...
openaire +1 more source
Welfare state and social spending: assessing the effectiveness and the efficiency of European social policies in 22 EU countries [PDF]
, 2018 This paper aims at analysing the effectiveness and the efficiency of social public expenditure in 22 European countries. We present a basic theoretical framework connecting the choice of the level of social protection to the median voter’s preferences ...
Antonelli, MARIA ALESSANDRA +1 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
We develop a model of R&D competition and collaboration in which individual firms carry out independent in-house research and also undertake joint research projects with other firms. We examine the impact of collaboration on in-house research and explore
Alexander Konovalov +2 more
core
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
An Economic Model for Bioprospecting Contracts [PDF]
This paper explores the use of a micro-economic model to analyse the provisions and parties of bioprospecting contracts. It focuses on the pharmaceutical industry as the representative biodiversity buyer, presenting an original theoretical framework that
Helen Ding +2 more
core
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Factors affecting farmers’ decision to join coffee producer cooperatives to improve their welfare
Agricultural and Resource EconomicsPurpose. The aim of this research is to evaluate the farmer characteristics, knowledge, social and economic factors that influence the decision to join a cooperative, as well as its impact on farmers’ welfare.
Intan Parumbuan Rombeallo +2 more
doaj +1 more source