Results 131 to 140 of about 1,195,997 (308)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
The good, the bad, and the ugly: Esping-Andersen's regime typology and the religious roots of the Western welfare state [PDF]
Esping-Andersen's 'Three World of Welfare Capitalism' has been the most influential contribution of recent years to the comparative welfare state research literature. According to Esping-Andersen, the welfare state basically comes in three variants: as a
Manow, Philip
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Confronted with high and growing inequality, causing increasing dissonance between European citizens and their political institutions, how can democracies ensure that their citizens believe that their political institutions are reliable and responsive?
Gillissen, Matthijs +2 more
openaire +3 more sources
, 2023 Over the past few decades, area-based initiatives have become a regularly employed means to tackle geographically concentrated deprivation. One such initiative is Tøyenløftet, which took place between 2014 and 2018 in the inner-eastern district of Tøyen in Oslo. A common criticism levied against area-based initiatives is that they have the potential to
openaire +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Perspective PoliticeThis study examines economic inequality in Latvia and Lithuania, focusing on the impact of social welfare policies on vulnerable groups in these countries.
Cătălin-Gabriel DONE, Romans GAGUNOVS
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Journal of Theoretical and Applied Electronic Commerce ResearchThe unequal status between manufacturers and live-streamers often undermines supply chain profitability and social welfare. However, the “volume guarantee” commission mode, designed to mitigate this issue, has proven ineffective in practice.
He Li, Juan Lu
doaj +1 more source