Results 141 to 150 of about 1,195,997 (308)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
AnimalsEvery year, many horses are transported by air. Alongside sport horses traveling to tournaments worldwide, mainly breeding horses, such as shuttle stallions and broodmares, thoroughbreds traded at auctions, and leisure horses are transported by air ...
Lucia Gräschke
doaj +1 more source
Assets, Markets and Poverty in Brazil [PDF]
This paper establishes a basis of research on the relationships among poverty, resources distribution and assets markets operation. The main objective is to help the implementation of capital enhancing policies towards the poor.
Marcelo Côrtes Nerí
core
Interchange Fee – Competitiveness of Payment Instruments [PDF]
, 2013 Purpose of the article: This study describes the markets of payment instruments. It focuses mainly on the systems of credit and debit cards. Authors identify key moments in theory used in this dilemma, called Tourist Test.
Heralecký, Tomáš, Sládková, Jitka
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Online networks and subjective well-being [PDF]
, 2014 We argue that the use of online networks may threaten subjective well-being in several ways, due to the inherent attributes of Internet-mediated interaction and through its effects on social trust and sociability.
Sabatini, Fabio, Sarracino, Francesco
core +3 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
, 2023 This thesis fundamentally reshapes understandings of working-class life and social mobility in modern Britain and disrupts existing histories of nineteenth-century institutional welfare. Focusing on the lives of 230 children who entered two Surrey-based reformatory and industrial schools between 1850 and 1895, it integrates qualitative and quantitative
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source