Results 61 to 70 of about 1,587,834 (268)

The relationship between ethical climate and organizational cynicism: mediating role of match and identification with the organization

open access: yesScientific Reports
Depending on its type, the ethical climate of an organization has either beneficial or detrimental effects in the workplace. However, there is a lack of knowledge about the role of employees’ attachment to the organization and the coherency of values ...
Marcin Wnuk   +2 more
doaj   +1 more source

The anatomy of well-being: understanding its psychosocial and sociodemographic dimensions

open access: yesFrontiers in Sociology
Migration processes should be analyzed in terms of their psychosocial impact within a multisystemic context. This study aims to identify the psychosocial and sociodemographic factors that influence the well-being of Portuguese migrants, focusing on ...
Carlos Barros   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The effects of social comparison and subjective financial well-being on subjective well-being

open access: yesEurope’s Journal of Psychology
Existing research on the antecedents of subjective well-being (SWB), which comprises life satisfaction and happiness, remains inconclusive. Some studies suggest that increasing income enhances SWB, while others emphasize the role of income comparison within reference groups in influencing SWB.
Renanita, Theda   +1 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Roles and Collaborative Practices of Drug Rehabilitation Social Workers and Community Drug Control Officers in Community-Based Drug Rehabilitation in China: A Qualitative Study

open access: yesSocial Sciences
Community-based drug rehabilitation (CBDR) in China involves multiple types of frontline workers, yet little empirical research has examined how these workers carry out their respective roles and collaborate in practice.
Zhihao Wei   +4 more
doaj   +1 more source

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