Results 91 to 100 of about 23,380,862 (254)

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

The feasibility and validity of the EQ-5D-Y and CHU9D in a challenging context: adolescent mental health in India

Journal of Patient-Reported Outcomes
Background Outcome measurement and economic evaluation in mental health are increasingly conducted in challenging contexts, including for young people, in low- and middle-income countries, and outside of the healthcare system.
Samuel J. Perry, Mutharaju Arelingaiah, Sphoorthi Prabhu, Amy Palmer, Siobhan Hugh-Jones, Janardhana Navaneetham, Hareth Al-Janabi   +6 more
doaj   +1 more source

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Experiences of Students with Learning Disabilities in Higher Education: A Scoping Review

Indian Journal of Psychological Medicine
Background: As the number of students with learning disabilities (SwLD) entering higher education (HE) increases, a need arises to improve the services provided to them by understanding their experiences.
Alen Kuriakose, Anekal C Amaresha
doaj   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Proceedings of the Twelfth National Symposium on Doctoral Research in Social Work [PDF]

, 2000
The University Archives has determined that this item is of continuing value to OSU's history.The Ohio State University College of Social WorkFront Matter: Proceedings title page, table of contents, and ...
Ohio State University. College of Social Work
core  

RCI or NCAHCP? Dilemmas About the Recognition of Psychiatric Social Work Professionals

Indian Journal of Psychological Medicine, 2022
Renjith R. Pillai, Srilatha Juvva, Jobin Tom, Sobhana H, Aravind Raj Elangovan   +4 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Adverse Childhood Experiences, Coping and Resilience in Persons with Alcohol Use Disorder and Their Non-drinking Siblings in High-density Families: A Case-control Study

Indian Journal of Psychological Medicine
Background: Adverse childhood experiences (ACEs) increase the odds of alcohol use disorder (AUD). Aim: To study the ACEs, coping, and resilience in persons with AUD and their non-drinking siblings from high-density families.
Sreenivasulu M., Vasuki Prathyusha, Sinu Ezhumalai, Gitanjali Narayanan, Pratima Murthy   +4 more
doaj   +1 more source

Lived experiences of women suffering from Tuberculosis in Kashmir: an interpretative phenomenological study

Frontiers in Global Women's Health
ObjectivesTo investigate women's experiences with tuberculosis and the challenges they face during their illness. It also explored the impact of infertility on their social relationships.MethodThe study used Interpretative Phenomenological Analysis to ...
Rubeena Akhter, Wakar Amin Zargar, Fayaz Ahmad Paul   +2 more
doaj   +1 more source