Results 81 to 90 of about 5,272,410 (354)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Understanding factors affecting fundamental school teachers’ use of technology in Luxembourg through a survey study

Heliyon
Over the last few decades, Information and Communication Technologies (ICT) have brought about significant disruptions across nearly every industry, including education.
Kateryna Ivanishchenko, Gilbert Busana, Robert A.P. Reuter   +2 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Integrating the teaching, learning and assessment of communication with children within the qualifying social work curriculum [PDF]

, 2015
Qualifying social work education must provide students with a variety of experiential, personalized, participatory, didactic and critically reflective learning opportunities across both the taught curriculum and in practice placements if deep learning of
Boylan, Briggs, Broadhurst, Carpenter, Commission for Social Care Inspection, Department for Education and Skills, Department of Health, Department of Health with the Evaluation of Social Work Degree Qualification in England Team, Egan, Gleeson, Horwath, Horwath, Huerta-Wong, Kolb, Koprowska, Lefevre, Luckock, Mensinga, Morgan, Moss, Napoli, Office for Standards in Education, Children's Services and Skills, Pope, Ruch, Smith, Social Work Task Force, Social Work Task Force, The Lord Laming, Trevithick, Trowell, Ward, Winter   +31 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Supporting Career Development and Employment: Benefits Planning, Assistance and Outreach (BPA&O) and Protection and Advocacy for Beneficiaries of Social Security (PABSS) [PDF]

, 2005
This training curriculum is dedicated to increasing knowledge and understanding of the Social Security Administration\u27s disability and return to work programs and work incentive provisions as prescribed in the Social Security Act and Ticket to Work ...
Golden, Thomas P., O’Mara, Susan, Ferrell, Connie, Sheldon, James R., Miller, Lucy Axton   +4 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Mobile device use in the primary school classroom and impact on pupil literacy and numeracy attainment: A systematic review

Campbell Systematic Reviews
Background Investment in mobile devices to support primary or elementary education is increasing and must be informed by robust evidence to demonstrate impact.
Claire Dorris, Karen Winter, Liam O'Hare, Edda Tandi Lwoga   +3 more
doaj   +1 more source

‘I can sleep at night’: examining the intersection of housing stability, addiction, and recovery among mothers who use drugs

Kōtuitui
Research on the housing crisis in Aotearoa New Zealand largely overlooks mothers who have substance use disorders, and their experiences of housing. In a study on mothers’ experiences of a residential parenting and drug rehabilitation programme, housing ...
Suzette C. Jackson, Laura Ann Chubb
doaj   +1 more source

Gratitude versus children's rights: An exploration mothers’ attitudes towards disability and inclusive education in Palestine

International Journal of Educational Research Open, 2020
The Palestinian National Authority has signed into law human rights protocols that promote, protect and ensure the rights of all children and the rights of persons with disabilities, including the right to an inclusive, equitable education.
Alison MacKenzie, Christine Bower, Mohammed Owaineh   +2 more
doaj   +1 more source