Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Why do some countries produce so much more output per worker than others? - A note [PDF]
In an important paper, Hall and Jones (1999) show that international differences in output per worker across 127 countries in 1988 are fundamentally determined by variations in, what they term, a country's ``social infrastructure''. This paper conducts a
Boyle, Gerry, McQuinn, Kieran
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LRR Focus: Worker Exchanges-A Powerful Way To Build Solidarity Across Borders [PDF]
, 1995 [Excerpt] A worker exchange - workers meeting with one another in each other\u27s communities - challenges both liberal guilt and self-centered nationalism as motivations for local organizing around trade issues.
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Supporting Older People’s Moves Between Different Care Settings: A Scoping Review
Journal of Long-Term CareContext: Moves between care settings in later life present significant challenges for older people. Social care practitioners play a significant role in supporting these moves, but sometimes lack the skills, confidence and resources to meet the needs of
Wenjing Zhang +4 more
doaj +1 more source
The 6 A's model of social worker associations and COVID-19: A preliminary insight. [PDF]
Qual Soc Work, 2023 Yadav R, Yadav A.
europepmc +1 more source
Monitoring Colleagues at Work: Profit-Sharing, Employee Ownership, Broad-Based Stock Options and Workplace Performance in the United States [PDF]
This study seeks to increase our understanding of worker reactions to shirking by analyzing two new questionson shirking from the 2002 General Social Science Survey (GSS).
Douglas Kruse +2 more
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Children’s views and experiences of their contact with social workers: a focused review of the evidence [PDF]
, 2010 "The review is ... aimed at exploring children’s reported experiences in terms of their relationship with social workers, as well as their views about social work tasks, and their perceptions concerning what makes a ‘good social worker’.
Oliver, Christine
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