Results 71 to 80 of about 119,754 (309)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Cloudworks: social networking for learning design [PDF]
, 2008 Why do some social networking services work and others fail? Can we apply the best of Web 2.0 principles to an educational context? More specifically can we use this as a means of shifting teaching practice to a culture of sharing learning ideas and ...
Brasher, Andrew +5 more
core +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Strong Reciprocity and Human Sociality [PDF]
Human groups maintain a high level of sociality despite a low level of relatedness among group members. The behavioral basis of this sociality remains in doubt. This paper reviews the evidence for an empirically identifiable form of prosocial behavior in
Herbert Gintis
core
FEBS Open Bio, EarlyView.This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart +4 more
wiley +1 more source
Molecular BrainAlzheimer’s disease (AD) is characterized by the loss of memory due to aggregation of misphosphorylated tau and amyloid beta (Aβ) plaques in the brain, elevated release of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and reactive oxygen ...
Mridula Bhalla, C. Justin Lee
doaj +1 more source
Effects of Sociality Level on Companion Dog Training through Food Reinforcement
Animals, 2020 The purpose of this study was to investigate the effect of sociality level in dogs using food reinforcement. The companion dogs living mostly inside (IS) and those living mostly outside (OS) groups were further classified into high sociality (HS) and low
Ok-Deuk Kang
doaj +1 more source
Distinguishing Topical and Social Groups Based on Common Identity and Bond Theory
, 2013 Social groups play a crucial role in social media platforms because they form the basis for user participation and engagement. Groups are created explicitly by members of the community, but also form organically as members interact.
Aiello, Luca Maria +3 more
core +1 more source