Results 91 to 100 of about 443,512 (297)

A systems approach to evaluate One Health initiatives [PDF]

, 2018
Challenges calling for integrated approaches to health, such as the One Health (OH) approach, typically arise from the intertwined spheres of humans, animals, and ecosystems constituting their environment.
Anderson, Aragrande, Argyris, Baum, Befani, Borgman, Boriani, Britt, Bunge, Canyon, Chigas, Chokshi, Craig, de Savigny, El-Jardali, Falzon, Fath, Fiol, Garcia, Garvin, Giesecke, Gould, Gunderson, Guns, Hadorn Hirsch, Hanin, Haxton, Hirsch Hadorn, Houe, Houghton, Huysman, Häsler, Ingram, Jones, Laing, Lang, Lattuca, Ledford, Lerner, Levitt, Lélé, Meadows, Moore, Mowles, Nancarrow, Nikitina, Ostrom, Paternoster, Pfeiffer, Piwowar, Piwowar, Piwowar, Pumain, Rabinowitz, Radeski, Raney, Redding, Reynolds, Romanelli, Rooke, Rüegg, Santa, Schelling, Scott, Stokols, Stokols, Tenopir, Thygeson, Trochim, Tsang, Wallace, Walter, Watkins, Whitehead, Whitehead, Whitmee, Williams, Yukl, Zinsstag   +78 more
core   +9 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The 10-tenets of adaptive management and sustainability: an holistic framework for understanding and managing the socio-ecological system [PDF]

, 2015
The three basic principles of sustainable development, relating to ecology, economy and society, have long been embedded within national and international strategies.
Barnard, Steve, Elliott, Michael
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A GIS-Based Geoportal for Land Management and Societal Acceptability in Mining: Case Study of MANAGEM Group, Morocco

International Journal of Computer Engineering and Data Science
The complexity of land management coupled with societal considerations in Morocco's mining sector grows over time. Challenges such as land security, traceability of mining footprints, and social acceptability in sensitive territories necessitate ...
Maroua Chattat, Sara Ait-Lamallam, Othmane Bahmade, Saad Azzaoui   +3 more
doaj   +4 more sources

Sustainability Evaluation of Nanotechnology Processing and Production

Chemical Engineering Transactions, 2015
This article discusses the current situation and challenges posed by nanotechnology from a sustainability point of view. It presents an objective methodology to evaluate the sustainability of nanotechnology products, based on a life cycle thinking ...
T.M. Mata, N.S. Caetano, A.A. Martins
doaj   +1 more source

The hedonic placebo effect of traditional medicines [PDF]

, 2012
To date, the scientific evidence on traditional medicines is scant and under-developed, yet, paradoxically individuals continue to use it and claim high satisfaction levels. What can explain this effect? Using self-collected data from Ghana we argue that
Costa-i-Font, Joan, Sato, Azusa
core  

Consistency and stability of risk indicators: The case of road infrastructures [PDF]

, 2018
Over the last decade, the World Road Association – PIARC and several European research projects, among which Ecoroads, have encouraged a promising reflection on risk analysis methods, acceptance criteria and safety practices applied to the road system ...
Di Mascio, Paola, Lombardi, Mara, Rossi, Giuliano   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Leading for Impact: Strengthening University Research Management Systems for Academic Excellence, Innovation, and Societal Development [PDF]

Global Journal of Environmental Science & Sustainability
Universities are critical engines of knowledge creation and societal transformation; however, many African institutions, particularly in Nigeria, struggle to cultivate mature and sustainable research cultures.
Enetimi Idah Seiyaboh, Morufu Olalekan Raimi
doaj   +1 more source