Results 151 to 160 of about 443,512 (297)
Indicator Politics: Modelling Societal Problems Under Real-World Conditions
Abstract This article explores the modelling of social problems from the point of view of experimental practices. As we observe an expansion of experimental spaces in the present, especially in the form of real-world labs (living labs), the question arises how knowledge for collective problem-solving is produced in the hybrid zone between ...
openaire +2 more sources
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
A Study of Effect of Geographical Factors on Societal Security (Case Study: Kerman Province)
تحقيقات جغرافيايی, 2016 Geographical spaces and political units affected from its location and natural environment and with the surrounding environment have interaction. It seems that security, especially societal security as the most fundamental concept of as social life ...
Hadi Veicy
doaj
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Unlocking Established Products Patient and Societal Value in Additional Indications [PDF]
Value in Health, 2016 Gabriel, S +10 more
openaire +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
The Report will contain a working definition and identification of the Working Poor area as to provide common notions for legal economic and social science scholars In addition the factors influencing inwork poverty will be ...
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African health sciences, 2006 Gunshot injuries were rare in Calabar before the Nigerian civil war. This has changed in subsequent years and has reached a near epidemic proportion in the last three years. These are caused by civil violence, police brutality and armed robberies.To evaluate the incidence, pattern and causes of gunshot injuries in this region and draw the attention of ...
Udosen, AM +3 more
openaire +2 more sources