Results 41 to 50 of about 20,866 (250)
Obesity, Bone Loss, and Periodontitis: The Interlink
Biomolecules, 2022 Obesity and periodontitis are both common health concerns that have given rise to considerable economic and societal burden worldwide. There are established negative relationships between bone metabolism and obesity, obesity and diabetes mellitus (DM ...
Pengfei Zhao, Aimin Xu, Wai Keung Leung
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Methadone and neonatal abstinence syndrome (NAS): what we think we know, but do not
Frontiers in Pediatrics, 2023 Since the first use of methadone to treat OUD in pregnancy in the 1970s, there has been a long, controversial, and confusing history of studies, regulatory actions, and practice changes that have clouded an accurate perception of methadone's use in ...
John J. McCarthy, Loretta P. Finnegan
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Current Research in Environmental SustainabilityIslands are bounded yet metabolically open socio-ecological systems whose viability is increasingly stressed by tourism pressure, climate variability, and high external dependence for energy and food.
Serafin Corral
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The rising influence of lipid metabolism in lung cancer: a global research perspective
Frontiers in OncologyBackgroundLung cancer is a prevalent malignant neoplasm globally and the leading cause of cancer-related mortality, posing a significant threat to human health and imposing a considerable societal burden.
Chaoqun Wang +7 more
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Multi-scale Integrated Analysis of Societal and Ecosystem Metabolism
, 2023 AbstractMuSIASEM provides a set of new narratives about the economic process that responds to the original challenges of the field of Ecological Economics. These alternative narratives can be used to identify and integrate four aspects of sustainability: (i) feasibility – compatibility with external constraints (processes outside of human control); (ii)
openaire +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
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Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source