Results 131 to 140 of about 3,967,313 (340)

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Breve reseña histórica del Colegio Médico de Cárdenas Short historical review of the Medical College of Cardenas

Revista Médica Electrónica, 2012
Se realizó una reseña histórica del Centro Médico Farmacéutico, de Cárdenas, fundado en 1882 por el doctor Dionisio José Sáez, siendo este su primer presidente. Este centro fue el primero en Cuba con tales características. Se esbozó el devenir del Centro
Junior Vega Jiménez
doaj  

Assessment of innovativeness, and price and reimbursement negotiation of medicines: recommendations of an expert panel

Global & Regional Health Technology Assessment
This paper illustrates the recommendations of a Working Group (WG) on the assessment of drugs innovativeness and the negotiation of price and reimbursement. The WG included researchers, institutions, clinicians, patient representatives and pharmaceutical
Claudio Jommi, Francesca Patarnello, Cosetta Bianchi, Giuliano Buzzetti   +3 more
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

“If I am here, it is because the system failed”: a critical qualitative study of global commercial clinical trials for advanced cancer in Chile

Globalization and Health
Background The pharmaceutical industry is a key global health actor given its crucial role in the development and testing of medicines. Within Latin America, Chile currently has the highest number of multinational commercial clinical trials per ...
Loreto Fernández-González, Gary Rodin, Jorge Sapunar, Amaya Perez-Brumer, Anne-Emanuelle Birn   +4 more
doaj   +1 more source

Health Biotechnology Innovation for Social Sustainability -A Perspective from China [PDF]

, 2011
China is not only becoming a significant player in the production of high-tech products, but also an increasingly important contributor of ideas and influence in the global knowledge economy.
Chen, Yantai, Ely, Adrian
core   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Early History of Oral Contraceptive Pill in Finland: The Diffusion of the New Contraceptive and Fertility Patterns

Finnish Yearbook of Population Research, 2011
The 1960s is often characterized as a decade of outstanding social and demographic changes in Western societies. The introduction of the contraceptive pill is assumed to have contributed to these changes.
Aura Pasila
doaj  

The effect of national culture on countries’ innovation efficiency [PDF]

This paper contributes to the link between social and cultural factors with countries innovation performance. By measuring 25 countries’ innovation efficiency with the use of conditional and unconditional DEA (Data Envelopment Analysis) frontiers the ...
Halkos, George, Tzeremes, Nickolaos
core   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source