Results 41 to 50 of about 6,284,919 (280)
Factors associated with basic scientific-academic capacity in medical students from Latin America
Iatreia, 2023 Introduction: There is limited evidence regarding student training on scientific and academic skills that are essential for medical training. Objective: To identify the factors associated to basic scientific-academic capacity in medical students from 11 ...
Mario J. Valladares-Garrido +4 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Les premières sociétés de géographie (Paris, Berlin, Londres)
Terra Brasilis, 2015 The foundation of the geographical societies of Paris, Berlin and London during the 1820's constitutes the major symbol of the creation of an independent and consistent discipline. In France, Prussia and Great-Britain, geographers expect that their field
Laura Péaud
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Minutes of the 2nd meeting of the Council of the International Union of Immunological Societies
, 1970 Council minutes from the second meeting of the International Union of Immunological Societies in Merligan ...
International Union of Immunological Societies;
core +1 more source
Global PediatricsAtopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease that frequently begins in early childhood and imposes a substantial clinical and psychosocial burden on affected patients and their families.
Massimo Pettoello-Mantovani +9 more
doaj +1 more source