Results 41 to 50 of about 216,191 (291)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Production of the scientific societies of medical students in Peru

, 2021
Introduction: Medical schools in Peru play an important role in scientific production and health development nationwide. The Scientific Societies of Medical Students promote research among their members.
Taype-Rondan, A., Alarcon-Ruiz, C.A., Fernandez-Chinguel, J.E.   +2 more
core  

CSSP ISSUE: OPEN ACCESS AND SCIENTIFIC SOCIETIES

, 2020
This is a position statement ratified by the Executive Board of the Council of Scientific Society Presidents in January 2020. Versions of it have been developed over the past decade by the Scholarly Publications and Data Committee of the CSSP chaired by ...
John Downing (3109326), Council of Scientific Society Presidents (8332864)   +1 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

European project on the competence in pediatric atopic dermatitis management in primary care: Pilot study in a Balkan region

Global Pediatrics
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease that frequently begins in early childhood and imposes a substantial clinical and psychosocial burden on affected patients and their families.
Massimo Pettoello-Mantovani, Tena Niseteo, Georgios Konstantinidis, Donjeta Bali, Angel Carrasco-Sanz, Maria Pastore, Mehmet Vural, Francesca Scaltrito, Tudor Lucian Pop, Giuseppe Buonocore   +9 more
doaj   +1 more source

Ukrainian Scientific Society in intellectual space late nineteenth – early twentieth century

Історико-політичні проблеми сучасного світу, 2017
This article examines creation of «Scientific Society named after Taras Shevchenko in Lviv» and «Ukrainian Scientific Society in Kiev». Trends of their activity witch provide joining with global academic community are discoursed. Particular attention is
Zinayida Zaytseva
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Documents of Foundations of Turkestan Scientific Societies in The National Archive of Uzbekistan

, 2023
Objectives: The primary objective of this article is to delve into the study of archival documents and scientific societies of Turkestan that operated during the second half of the 19th to the early 20th centuries.
Musoyev, Umirzoq U., Salomova, Lutfiya I., Nazarov, Azizbek Y., Botirov, Elbek A., Nematov, Ismoil N., Yusupov, Mansur M.   +5 more
core   +1 more source

Medical education for undergraduate research: Proposals from the experience of two national student conferences of the Universidad de Valparaíso

Medwave
Introduction Scientific research promotes the development of essential skills for medical practice. However, student participation in research projects is low, with multiple limitations and students' perceptions of deficient research skills.
Carlos Cabrera-Ubilla, Sebastián Almarza Santander, Marcelo Arancibia, María Elizabeth Guerra-Zúñiga   +3 more
doaj   +1 more source