Results 71 to 80 of about 216,191 (291)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

ORGANIZATIONAL AND METHODICAL FEATURES OF THE ACTIVITY OF STUDENT SCIENTIFIC SOCIETIES, ORIENTED TO PERSONAL SELF-DEVELOPMENT OF YOUTH

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2018
The research is aimed at identifying organizational and methodological approaches to the organization of social and cultural activities, oriented to the student’s self-development.
E. I. Pankova
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Participation of Statistical Committees and Scientific Public Organizations of Siberia in Population Censuses in the Second Half of the 19th Century

Научный диалог, 2018
The interrelation between development of the state, administrative statistics, scientific knowledge and organization of population censuses in the European countries and Russia is considered.
E. V. Igumnov
doaj   +1 more source

Trust and reputation in dynamic scientific communities

, 2004
The formation of collaboration networks (or communities) is an important latent effect in many computational science undertakings. Generally, collaboration networks bring together participants who wish to achieve some common goal or outcome (often over ...
Omer F. Rana, Hinze, Annika, O.F. Rana, Annika Hinze, A. Hinze, Rana, Omer F.   +5 more
core   +1 more source

Characterizing a scientific elite: the social characteristics of the most highly cited scientist in environmental science and ecology [PDF]

, 2010
In science, a relatively small pool of researchers garners a disproportionally large number of citations. Still, very little is known about the social characteristics of highly cited scientists.
Lortie, C., John N. Parker, Lortie, Christopher, Allesina, Stefano, Christopher Lortie, Parker, John N., John Parker, Stefano Allesina, Allesina, S., Parker, J.N.   +9 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Scientific associations - an analysis of 157 Danish scientific associations (learned societies J.D.Hammond scientific societies Anna Delicado scientific associations Deciplinary associations Wiberley Jr., S.E. science associations Evan Schofer)

, 2019
learned societies J.D.Hammond scientific societies Anna Delicado scientific associations Deciplinary associations Wiberley Jr., S.E.
Follend, Anders Bjørn Møller, Hald, Janus Christian   +1 more
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source