Results 121 to 130 of about 3,607,669 (312)

Quase adulta, quase velha: por que antecipar as fases do ciclo vital?

Interface: Comunicação, Saúde, Educação
A partir de duas observações em gerações diferentes, identifica-se um fenômeno de antecipação da passagem pelas fases do ciclo vital que merece uma interpretação. Muitas jovens engravidam, casando ou não, e se tornam mães.
Russel Parry Scott
doaj  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The expressive and formative methods of sculptors in Arabian and African societies Effected by the surrounding conflicts

Maǧallaẗ Al-Turāṯ wa Al-Taṣmīm
Talking about contemporary Arabian and African sculpture is worthy of consideration to study because we truly need to discuss "conflicts" as a concept and its impact on creating sculptural works due to these surrounding changes that peoples and societies
Lecturer.Nahla Wagdy Mohamed
doaj   +1 more source

Are societies becoming more self-centric? Evidence from five decades of popular music spanning three continents. [PDF]

PLoS One
Golubickis M, Jalalian P, Masroujah LS, Selvaraj ES, Sharma Y, Seow SH, Borrego-Guerrero A, Marr S, Macrae CN.   +8 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Strong-Ties and Weak-Ties Rationalities: Predicting Public Stigma, Support Networks, and Health Behaviours During the COVID-19 Pandemic Across Four Societies. [PDF]

Int J Psychol
Ting RS, Terpstra-Tong J, Hta MKZ, Xie ZY, Chen YF, Bond MH, Yeh KH, Sundararajan L.   +7 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Evaluating conflict-of-interest governance among Canadian medical societies using a novel assessment tool: A cross-sectional study. [PDF]

PLoS One
Rickard E, Lexchin J.
europepmc   +1 more source