Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...
Craig M. McDonald +74 more
wiley +1 more source
An Address on Trauma in Relation to Disease of the Nervous System: Presidential Address to the Manchester Medical Society [PDF]
, 1904 J. S. Bury
openalex +1 more source
Pre‐Diagnostic Features of Multiple Sclerosis in a Diverse UK Cohort: A Nested Case–Control Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Many patients with Multiple Sclerosis (MS) experience nonspecific symptoms prior to diagnosis. This period—the 'MS prodrome'—has been described in socio‐economically homogeneous cohorts to date. It remains unclear to what extent events prior to an MS diagnosis differ according to social determinants of health. Methods We conducted a
Pooja Tank +3 more
wiley +1 more source
An Address on Acute Manifestations of Chronic Disease: Delivered at the Opening of the Winter Session of the Midland Medical Society [PDF]
, 1902 J Mitchell Bruce
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo +13 more
wiley +1 more source
Africanos Centrais no Rio de Janeiro Oitocentista: aspectos e conexões
Acervo, 2017 Neste estudo, procuro fazer um panorama das irmandades religiosas, sociedades beneficentes e relações familiares como formas de inserção dos africanos centrais no Rio de Janeiro oitocentista.
Nilma Teixeira Accioli
doaj
The Purvis Oration ON THE DIAGNOSIS OF ORGANIC FROM FUNCTIONAL AFFECTIONS OF THE NERVOUS SYSTEM: Delivered before the West Kent Medico-Chirurgical Society [PDF]
, 1908 J. S. Risien Russell
openalex +1 more source
CSF Mitochondrial DNA: Biomarker of Body Composition and Energy Metabolism in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cerebrospinal fluid (CSF) cell‐free mitochondrial DNA (cf‐mtDNA) is a potential biomarker for Parkinson's disease (PD), but its clinical relevance remains unclear. We investigated associations between CSF cf‐mtDNA levels, body composition, nutritional status, and metabolic biomarkers in PD. Methods CSF cf‐mtDNA levels, defined as the
Yasuaki Mizutani +11 more
wiley +1 more source
Going from Theory to Practice: The Mixed Success of Approval Voting [PDF]
Approval voting (AV) is a voting system in which voters can vote for, or approve of, as many candidates as they like in multicandidate elections. In 1987 and 1988, four scientific and engineering societies, collectively comprising several hundred ...
Brams, S.J., Fishburn, P.C.
core