Results 181 to 190 of about 16,233,922 (313)

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

open access: yesAdvanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou   +13 more
wiley   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

open access: yesAdvanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He   +12 more
wiley   +1 more source

Climate Change is Rewriting the Hydroclimatic Operating Envelope of Mines

open access: yesAdvanced Science, EarlyView.
Climate change is shown to shift the hydroclimatic operating envelope of mines: 16.2% of represented mine locations have already changed Köppen subtype, rising to 42.5% by late century under SSP5‐8.5. Divergent water trajectories are filtered through geology, infrastructure and lifecycle stage, indicating that adaptation requires monitored, scenario ...
Haoxuan Yu   +3 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

open access: yesAdvanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun   +12 more
wiley   +1 more source

Implementation of the Use of Ethnomedicinal Plants for Curing Diseases in the Indian Himalayas and Its Role in Sustainability of Livelihoods and Socioeconomic Development. [PDF]

open access: yesInt J Environ Res Public Health, 2021
Kumar M   +8 more
europepmc   +1 more source

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