Results 141 to 150 of about 222,094 (300)

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...
Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu, Bowen Zhong, Qihao Leng, Xiaohua Wu, Minfeng Chen, Lingfang Li, Yuan Li, Xin Jin, Long Wang, Jian Cao, Xin Li, Mingzhu Yin, Xiang Chen   +21 more
wiley   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

The Effects of Home Quarantine Duration, Parental Emotional Intelligence, and Family Socioeconomic Status on Children’s Anxiety During the Pandemic: A Survey of 29,550 Parents

Psychology Research and Behavior Management
Jiaxin Xiang,1,* Jing Wu,2,* Chongyan Lian,3 Xiaoxiao Lin1 1School of Education, Guangzhou University, Guangzhou, Guangdong, 510006, People’s Republic of China; 2Department of Early Childhood Education, Shenzhen Polytechnic University, Shenzhen ...
Xiang J, Wu J, Lian C, Lin X
doaj  

Assessing socioeconomic status through dental and associated tissue characteristics: A cross-sectional study for human identification [version 2; peer review: 2 approved]

F1000Research
Background Dental identification methods are employed to determine a person’s identity in forensic odontology. Additionally, analyzing a person’s teeth can provide insights into their socioeconomic status, which may assist in the process of ...
Srikant Natarajan, Shwetha Yellapurkar, Amita Juanita Lewis, CEENA DENNY, Nandita KP, Jasmine Jophy   +5 more
doaj   +1 more source

Role of ethnicity and socioeconomic status (SES) in the presentation of retinoblastoma: findings from the UK. [PDF]

BMJ Open Ophthalmol, 2020
Bourkiza R, Cumberland P, Fabian ID, Abeysekera H, Parulekar M, Sagoo MS, Rahi J, Reddy MA.   +7 more
europepmc   +1 more source

Socioeconomic Differences in the Adoption of New Medical Technologies [PDF]

New medical technologies hold tremendous promise for improving population health, but they also raise concerns about exacerbating already large differences in health by socioeconomic status (SES).
Dana Goldman, James P. Smith
core  

Socioeconomic Status and Student Academic Performance [PDF]

, 2016
The injustices imposed on children based on their home, community, and social environment ultimately becomes injustices they encounter throughout their lives as well, post their school years (Coleman, et al, 1966).
Nillas, Faculty Advisor, Leah, Spain, Ashley   +1 more
core   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Assessing socioeconomic status through dental and associated tissue characteristics: A cross-sectional study for human identification [version 3; peer review: 2 approved]

F1000Research
Background Dental identification methods are employed to determine a person’s identity in forensic odontology. Additionally, analyzing a person’s teeth can provide insights into their socioeconomic status, which may assist in the process of ...
Srikant Natarajan, Shwetha Yellapurkar, Amita Juanita Lewis, CEENA DENNY, Nandita KP, Jasmine Jophy   +5 more
doaj   +1 more source