Results 131 to 140 of about 35,617 (253)

Sodium-Glucose Co-Transporter 2 Inhibitors' Use in Muscular Dystrophy-Related Cardiomyopathy: Data from a Single-Center Experience. [PDF]

J Clin Med
Matassini MV, Coraducci F, Mancini N, Campanella F, Carabotta C, Shkoza M, Pettinari L, Coccia M, Russo AD, Marini M.   +9 more
europepmc   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Cost-Effectiveness of Sodium-Glucose Co-Transporter-2 Inhibitors and Angiotensin Receptor-Neprilysin Inhibitors by Ejection Fraction and Drug Pricing in the United States: A Systematic Review. [PDF]

Circ Popul Health Outcomes
Alfie TJ, Wasfy JH, Kazi DS, Januzzi JL, Bellows BK, Cohen LP.   +5 more
europepmc   +1 more source

Multi‐Stimuli Responsive Magneto‐Coacervate Droplets for Selective Molecular Enrichment and Programmable Manipulation

Advanced Science, EarlyView.
ABSTRACT Coacervate droplets formed via liquid–liquid phase separation offer unique opportunities as microreactors and delivery vehicles due to their ability to selectively concentrate biomolecules and support biochemical reactions. However, their passive nature severely restricts precise spatial and temporal control, posing barriers to practical ...
Kailang Liu, Haocheng Ran, Haohui Ou, Peiying Chen, Cheng Qi, Tiantian Kong, Zhou Liu   +6 more
wiley   +1 more source

The preventive effect of sodium-glucose co-transporter-2 inhibitors on life-threatening arrhythmias in patients with chronic kidney disease: a meta-analysis. [PDF]

Front Cardiovasc Med
Yang Q, Jia Y, Li Z, Yu Y, Dang Y.
europepmc   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Sodium Glucose Co-Transporter 2 Inhibitors in Patients With Heart Failure and Transcatheter Aortic Valve Replacement. [PDF]

JACC Adv
Yasmin F, Hamza M, Fahim MAA, Asghar MS, Ullah W, Alraies MC.   +5 more
europepmc   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Fournier's gangrene and sodium-glucose co-transporter 2(SGLT2) inhibitors: Our experience

Indian Journal of Endocrinology and Metabolism, 2019
Ashwitha S Dass, Gloria Immaculate, Arpandev Bhattacharyya   +2 more
doaj   +1 more source

Sodium-glucose co-transporter 2 inhibitors and obesity-associated cancers in people with type 2 diabetes: A real-world observational study. [PDF]

Diabetes Obes Metab
Ipaye T, Goldney J, Yates T, Zaccardi F, Khunti K, Akalestou E, Davies MJ, Brown K, Papamargaritis D.   +8 more
europepmc   +1 more source