Results 161 to 170 of about 29,662,057 (278)

Sodium-glucose co-transporter 2 inhibitors are negatively correlated with hypomagnesemia in elderly patients with type 2 diabetes. [PDF]

Front Nutr
Lin L, Jin Y, Jin L, Wang B, Xu J, Chen S.   +5 more
europepmc   +1 more source

Translational Barriers and AI‐Driven Challenges of Microfluidics‐Enabled Wearables and Implantable Systems in Personalized Medicine

Advanced Science, EarlyView.
An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo   +3 more
wiley   +1 more source

Early initiation of sodium-glucose co-transporter-2 inhibitors in heart failure patients: a nationwide study. [PDF]

ESC Heart Fail
Gautier P, Lafaurie M, Bouisset F, Delmas C, Cherbi M, Lhermusier T, Elbaz M, Montastruc F.   +7 more
europepmc   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Continuation of sodium-glucose co-transporter 2 inhibitors in advanced chronic kidney disease: a retrospective study with inverse probability of treatment weighting analysis. [PDF]

Clin Kidney J
Ng JK, Chow EY, Fung WW, Chan GC, Chow KM, Szeto CC.   +5 more
europepmc   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Fournier's gangrene and sodium-glucose co-transporter 2(SGLT2) inhibitors: Our experience

Indian Journal of Endocrinology and Metabolism, 2019
Ashwitha S Dass, Gloria Immaculate, Arpandev Bhattacharyya   +2 more
doaj   +1 more source

Sodium-Glucose Co-Transporter 2 Inhibitors' Use in Muscular Dystrophy-Related Cardiomyopathy: Data from a Single-Center Experience. [PDF]

J Clin Med
Matassini MV, Coraducci F, Mancini N, Campanella F, Carabotta C, Shkoza M, Pettinari L, Coccia M, Russo AD, Marini M.   +9 more
europepmc   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Implementation of sodium-glucose co-transporter 2 inhibitors use in patients with heart failure across the ejection fraction: data from the Swedish heart failure registry. [PDF]

Eur Heart J Qual Care Clin Outcomes
Ferrannini G, Musella F, Benson L, Valente V, Lindberg F, Boccalatte M, Corovic Cabrera C, Dahlström U, Lund LH, Stolfo D, Savarese G.   +10 more
europepmc   +1 more source