Results 191 to 200 of about 118,941 (325)

Developmentally Inspired, Mechanical–Metabolic Dual Gradient Osteochondral Constructs Bridging Regeneration and Therapeutic Screening

Advanced Science, EarlyView.
A developmentally inspired osteochondral construct integrates mechanical and metabolic dual gradients within a 3D‐printed platform. Human MSC spheroids are spatially directed to form cartilage–bone interfaces, enabling evaluation of regeneration without biochemical reagents and assessment of drug responses. This physiologically relevant, phase‐specific
Yurim Choi, Wonjun Jang, Raehui Kang, Ulziituya Batjargal, Jihyeon Song, Soojin Park, MinSeok Kim, Hyobum Cho, Junhyung Kim, Yu Shrike Zhang, Han‐Jun Kim, Junmin Lee   +11 more
wiley   +1 more source

Sodium Glucose Co-Transporter 2 Inhibitors in Patients With Heart Failure and Transcatheter Aortic Valve Replacement. [PDF]

JACC Adv
Yasmin F, Hamza M, Fahim MAA, Asghar MS, Ullah W, Alraies MC.   +5 more
europepmc   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Sodium-glucose Co-transporter 2 Inhibitors on Body Composition in Lean Heart Failure With Preserved Ejection Fraction. [PDF]

Korean Circ J
Shimoya Y, Kagami K, Yuasa N, Tani Y, Harada T, Murakami T, Yamada E, Wada N, Ishii H, Obokata M.   +9 more
europepmc   +1 more source

The potential role and rationale for treatment of heart failure with sodium–glucose co‐transporter 2 inhibitors

European Journal of Heart Failure, 2017
J. Butler, C. Hamo, G. Filippatos, S. Pocock, R. Bernstein, M. Brueckmann, A. Cheung, J. George, J. Green, J. Januzzi, S. Kaul, C. Lam, G. Lip, N. Marx, P. McCullough, C. Mehta, P. Ponikowski, J. Rosenstock, N. Sattar, A. Salsali, B. Scirica, Sanjiv J. Shah, H. Tsutsui, S. Verma, C. Wanner, H. Woerle, F. Zannad, S. Anker   +27 more
semanticscholar   +1 more source

Deep Learning‐Powered Scalable Cancer Organ Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
This scalable, low‐cost Organ Chip platform, made via injection molding, uses capillary pinning for hydrogel confinement and supports versatile tissue coculture and robust imaging. Deep learning enables label‐free, sensitive phenotypic analysis.
Yu‐Chieh Yuan, Beibei Xu, Jenna McCormack, XuHai Huang, Jingzhe Ma, Thomas Marshall, Yacong Sun, Hardeep Singh, Alyssa Fanelli, Gauri Kulkarni, Ji Hye Seo, Paige Gilbride, Bing Wei, Bo Wang, Yanyan Liu, Fei Ma, Lin Zhou, Shuyang Wang, Xiaohua Qian, Zhiyong Xie, Polina Golland, Longlong Si, Yu Shrike Zhang, Xin Xie, Haiqing Bai   +24 more
wiley   +1 more source

Expanding the Therapeutic Landscape: Sodium-Glucose Co-transporter 2 Inhibitors in Kidney Transplant Recipients. [PDF]

Cureus
Khan A, Ali MM, Hamer R.
europepmc   +1 more source

Sodium-glucose co-transporter 2 inhibitors and cardiovascular outcomes: A systematic review and meta-analysis

European Journal of Preventive Cardiology, 2018
M. Usman, T. Siddiqi, M. M. Memon, M. Khan, W. Rawasia, Muhammad Talha Ayub, Jayakumar Sreenivasan, Y. Golzar   +7 more
semanticscholar   +1 more source

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, EarlyView.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

From Glucose Transport to Microbial Modulation: The Impact of Sodium Glucose Co-Transporter-2 Inhibitors on the Gut Microbiota. [PDF]

Med Sci (Basel)
George MY, Gamal NK, Safwat K, Mamdouh M, AbdElFatah A, Atallah A, Cerchione C.   +6 more
europepmc   +1 more source