Results 261 to 270 of about 22,963 (277)

Sodium Iodide Symporter in Thyroid Carcinoma

2012
Thyroid iodide uptake is essential for the clinical application of radioiodine in patients with well-differentiated thyroid carcinoma. Iodide uptake occurs across the plasma membranes of thyroid follicular cells and cancer cells via an active transporter process mediated by sodium iodide symporter (NIS).
openaire   +2 more sources

Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.

Journal of Medicinal Chemistry, 2019
An inverse agonist of estrogen-related receptor-γ (ERRγ), an orphan nuclear receptor encoded by E srrg, enhances sodium iodide symporter-mediated radioiodine uptake in anaplastic thyroid cancer (ATC) cells, thereby facilitating responsiveness to ...
Jina Kim, Jaeyoung Song, H. Ji, E. Yoo, Jae-Eon Lee, Sang Bong Lee, J. Oh, Seungmi Lee, Ji-sun Hwang, Heeseok Yoon, Dong-Su Kim, Su-Jeong Lee, Minseon Jeong, Sungwoo Lee, Kyung-Hee Kim, Hueng-Sik Choi, Sang Woo Lee, K. Park, Inkyu Lee, S. Kim, Hayoung Hwang, Y. Jeon, Jungwook Chin, S. Cho   +23 more
semanticscholar   +1 more source

Sodium Iodide Symporter in the Fight Against Thyroid Cancer

Future Oncology, 2013
n radioiodide n signal transduction inhibitor n sodium iodide symporter n thyroid cancer More than 60 years of experience of radioiodide therapy has indicated its usefulness for the treatment of differentiated thyroid cancer. This therapy utilizes the differentiated function of thyroid cells, namely iodide uptake for thyroid hormone synthesis.
openaire   +2 more sources

Homologies of the thyroid sodium-iodide symporter with bacterial and viral proteins

Journal of Endocrinological Investigation, 1999
We have demonstrated that Na+/I- symporter (NIS), a novel thyroid autoantigen, has local amino acid sequence homologies with the other thyroid autoantigens: Thyroglobulin (Tg), thyroid peroxidase (TPO) and thyrotropin receptor (TSH-R). These homologies concern the 4th, 5th, 6th extracellular loop and the beginning of the intracellular tail.
BENVENGA, Salvatore, ALESCI S, TRIMARCHI, Francesco, FACCHIANO A.   +3 more
openaire   +5 more sources

Cloning of the Human Sodium Iodide Symporter

Biochemical and Biophysical Research Communications, 1996
The iodide concentrating activity of the thyroid gland is essential to the production of thyroid hormone and also provides a mechanism for the treatment of thyroid cancer by radioiodine ablation. We report here the nucleotide and amino acid sequence of the human sodium iodide symporter (hNIS), which mediates the iodide uptake activity in the thyroid ...
Patricia A. Smanik, Sissy M. Jhiang, Shunhua Xing, Kwon-Yul Ryu, Tara L. Furminger, Qing-Rong Liu, Ernest L. Mazzaferri   +6 more
openaire   +3 more sources

Sodium Iodide Symporter and Pendrin Expression in Human Thyroid Tissues

Thyroid, 2001
Thyroid cells synthesize thyroid hormones through a multistep process during which iodide is transported through the basolateral and the apical membranes of thyrocytes. Two genes that participate in these transports and the corresponding proteins, namely sodium iodide symporter (NIS) and pendrin, the product of the Pendred syndrome gene, have recently ...
MIAN, CATERINA, LACROIX L, ALZIEU L, NOCERA M, TALBOT M, BIDART JM, SCHLUMBERGER M, CAILLOU B.   +7 more
openaire   +4 more sources

Sodium iodide symporter expression and radioiodine distribution in extrathyroidal tissues

Journal of Endocrinological Investigation, 2004
The functional role of the sodium iodide symporter (NIS) in extrathyroidal tissues was investigated by examining its mRNA and protein expression, together with the evidence of radioiodine (131)I uptake in 302 patients who underwent (131)I total body scanning, following the administration of high doses of (131)I for a papillary or follicular thyroid ...
R. Bruno, P. Giannasio, RONGA, Giuseppe, E. Baudin, J. P. Travagli, D. Russo, FILETTI, SEBASTIANO, M. Schlumberger   +7 more
openaire   +4 more sources

Visualisation of sodium-iodide symporter

European Journal of Nuclear Medicine and Molecular Imaging, 2005
Jordi Fuertes, Montserrat Estorch, Valle Camacho, Luis De Andres, Albert Flotats, A. J. Rodríguez, Ignasi Carrió   +6 more
openaire   +3 more sources

The sodium iodide symporter and thyroid disease

Clinical Endocrinology, 2002
Peter P.A. Smyth, Roisin M. Dwyer
openaire   +2 more sources

Regulation of sodium/iodide symporter.

Reviews in endocrine & metabolic disorders, 2000
openaire   +3 more sources