Results 41 to 50 of about 357,651 (286)

Acidose metabólica na infância: por que, quando e como tratá-la? [PDF]

, 2007
Objectives: To critically discuss the treatment of metabolic acidosis and the main mechanisms of disease associated with this disorder; and to describe controversial aspects related to the risks and benefits of using sodium bicarbonate and other ...
Andrade, Olberes Vitor Braga de, Ihara, Flavio de Oliveira, Troster, Eduardo Juan   +2 more
core   +1 more source

Prophylactic perioperative sodium bicarbonate to prevent acute kidney injury following open heart surgery: a multicenter double-blinded randomized controlled trial. [PDF]

PLoS Medicine, 2013
Preliminary evidence suggests a nephroprotective effect of urinary alkalinization in patients at risk of acute kidney injury. In this study, we tested whether prophylactic bicarbonate-based infusion reduces the incidence of acute kidney injury and ...
Michael Haase, Anja Haase-Fielitz, Michael Plass, Hermann Kuppe, Roland Hetzer, Claire Hannon, Patrick T Murray, Michael J Bailey, Rinaldo Bellomo, Sean M Bagshaw   +9 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Contrast-associated acute kidney injury : does it really exist, and if so, what to do about it? [PDF]

, 2019
For decades, when contrast agents are administrated, physicians have been concerned because of the risk of inducing acute kidney injury (AKI). Recent literature questions the existence of AKI induced by contrast, but animal studies clearly showed harmful
Hoste, Eric, Vandenberghe, Wim
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Sodium chloride vs. sodium bicarbonate for the prevention of contrast medium-induced nephropathy: a randomized controlled trial [PDF]

, 2017
Aims The most effective regimen for the prevention of contrast-induced nephropathy (CIN) remains uncertain. Our purpose was to compare two regimens of sodium bicarbonate with 24 h sodium chloride 0.9% infusion in the prevention of CIN.
Breidthardt, Tobias, Burri, Emanuel, Christ, Andreas, Hartwiger, Sabine, Kalbermatter, Stefan, Klima, Theresia, Marana, Ivana, Marenzi, Giancarlo, Mueller, Christian, Schindler, Christian, Uthoff, Heiko   +10 more
core  

Time to Optimize Supplementation: Modifying Factors Influencing the Individual Responses to Extracellular Buffering Agents. [PDF]

, 2018
Blood alkalosis, as indicated by an increased blood bicarbonate concentration and pH, has been shown to be beneficial for exercise performance. Sodium bicarbonate, sodium citrate, and sodium or calcium lactate, can all result in increased circulating ...
Aedma, Artioli, Ball, Bangsbo, Belfry, Ben-Zaken, Bishop, Bishop, Bogdanis, Callahan, Carr, Carr, Carr, Carr, Christensen, Correia-Oliveira, Costill, Cox, Cupeiro, Cupeiro, Danaher, Driller, Duncan, Egger, Fabiato, Fahey, Fitts, Flueck, Freis, Froio de Araujo Dias, Gaitanos, Gough, Gough, Gough, Hargreaves, Hausswirth, Hecksteden, Hermansen, Higgins, Higgins, Hobson, Horswill, Jones, Jubrias, Juel, Juel, Juel, Juel, Katz, Knapik, Kowalchuk, Krustrup, Kupcis, Lancha Junior, Lavender, Lean, Linossier, Maciejewski, Mainwood, Matson, McGinley, McGinley, McNaughton, McNaughton, McNaughton, McNaughton, McNaughton, McNaughton, McNaughton, McNaughton, Miller, Morris, Morris, Mueller, Northgraves, Oliveira, Painelli, Painelli, Pasqua, Peart, Pilegaard, Pilegaard, Pilegaard, Price, Price, Robergs, Russell, Sahlin, Saunders, Saunders, Saunders, Sawczuk, Schabort, Siegler, Siegler, Siegler, Siegler, Siegler, Sparks, Stephens, Turnberg, Urwin, Vaher, Van Montfoort, van Someren, Webster, Westerblad   +106 more
core   +2 more sources

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Texture profile of surimi-like material from mechanically deboned turkey meat

Brazilian Journal of Food Technology, 2021
The study aimed to evaluate the textural properties of turkey surimi-like (TSL) gels from mechanically deboned turkey meat (MDTM) by washing procedures.
Armando Abel Massingue, Mariele Maria de Oliveira Paula, Ana Paula Rocha, Gabriela de Barros Silva Haddad, Eloá Lourenço do Carmo, Alcinéia de Lemos Souza Ramos, Eduardo Mendes Ramos   +6 more
doaj   +1 more source