Results 81 to 90 of about 14,950 (202)

Unexpected stable stoichiometries of sodium chlorides [PDF]

open access: yes, 2013
Sodium chloride (NaCl), or rocksalt, is well characterized at ambient pressure. Due to the large electronegativity difference between Na and Cl atoms, it has highly ionic chemical bonding, with stoichiometry 1:1 dictated by charge balance, and B1-type crystal structure.
arxiv   +1 more source

Stimulation of Enzyme Reaction Rates by Crystalline Substrate Irradiation: Dependence on Identity of Irradiated Substance [PDF]

open access: yesarXiv, 2013
The study reported here concerns a phenomenon, discovered and extensively investigated by Sorin Comorosan, wherein enzyme initial reaction rates are enhanced as a consequence of incorporation of solutions derived from previously irradiated crystalline material into the reaction medium.
arxiv  

Mechanism of Anion Exchange and Small-Molecule Inhibition of Pendrin [PDF]

open access: yes
Pendrin (SLC26A4) is an anion exchanger that mediates bicarbonate (HCO3−) exchange for chloride (Cl−) and is crucial for maintaining pH and salt homeostasis in the kidney, lung, and cochlea. Pendrin also exports iodide (I−) in the thyroid gland.
Gil-Iturbe, Eva   +5 more
core   +2 more sources

Nucleation kinetics in drying sodium nitrate aerosols [PDF]

open access: yesarXiv, 2019
A quantitative understanding of the evaporative drying kinetics and nucleation rates of aqueous based aerosol droplets is important for a wide range of applications, from atmospheric aerosols to industrial processes such as spray drying. Here, we introduce a numerical model for interpreting measurements of the evaporation rate and phase change of ...
arxiv  

LeuT Conformational Sampling Utilizing Accelerated Molecular Dynamics and Principal Component Analysis [PDF]

open access: yes, 2012
Monoamine transporters (MATs) function by coupling ion gradients to the transport of dopamine, norepinephrine, or serotonin. Despite their importance in regulating neurotransmission, the exact conformational mechanism by which MATs function remains ...
Gedeon, Patrick C.   +3 more
core   +1 more source

Glycine transporters GlyT1 and GlyT2 are differentially modulated by glycogen synthase kinase 3β [PDF]

open access: yes, 2016
© 2014 Elsevier Ltd. All rights reserved. Inhibitory glycinergic neurotransmission is terminated by the specific glycine transporters GlyT1 and GlyT2 which actively reuptake glycine from the synaptic cleft.
Giménez, C.   +4 more
core   +1 more source

Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells

open access: yesThyroid Research, 2018
Background and AimsThe activating mutation BRAFV600E is a frequent genetic event in papillary thyroid carcinomas (PTC). Mutation BRAFV600E is associated with the loss of a sodium/iodine symporter (NIS), and subsequent radioiodide-refractory (RAI ...
Honglai Zhang, Dong Chen
semanticscholar   +1 more source

SLC transporters as therapeutic targets: Emerging opportunities [PDF]

open access: yes, 2015
Solute carrier (SLC) transporters-a family of more than 300 membrane-bound proteins that facilitate the transport of a wide array of substrates across biological membranes-have important roles in physiological processes ranging from the cellular uptake ...
Giacomini, Kathleen M.   +3 more
core   +1 more source

Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.

open access: yesCirculation, 2016
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin, and canagliflozin, are now widely approved antihyperglycemic therapies. Because of their unique glycosuric mechanism, SGLT2 inhibitors also reduce weight.
H. Heerspink   +4 more
semanticscholar   +1 more source

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