CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 1988 Muscle tension recordings were made from earthworm body wall muscle and the action of acetylcholine, cholinomimtics and cholinolytics examined. The effect of cholinergic agents on muscle twitches induced following field stimulation was also investigated.
Hassoni, Abdul-Nabi Atya, Hassoni, A.A
core
Isolation and reactivity of sodium benzyl cations
Nature CommunicationsCarbanions are an important class of reactive species used as nucleophiles in C-C bond-forming reactions. Such reactive carbanions are generated by deprotonating relatively acidic C-H bonds using strong bases like sodium/potassium hydroxides or amides ...
Suban Kundu +5 more
doaj +1 more source
Sodium Metabisulfite Inhibits Acanthamoeba Trophozoite Growth through Thiamine Depletion
PathogensAcanthamoeba keratitis (AK) is a severe infection of the cornea. Prevention and treatment are difficult due to the inefficacy of currently available compounds.
Ronnie Mooney +11 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Some spectroscopic, kinetic and equilibria studies of Cyano- and nitro- substituted anisoles and phenols and their reactions with nucleophiles [PDF]
, 1990 The reactions of ring-activated alkyl aryl ethers with nucleophiles have been examined. The main pathways involve attack by the nucleophiles at the alkyl carbon to give substituted phenoxide ions, or at ring carbon atoms to give σ-adducts.
Castilho, Paula C.M.F.
core
Surfactant and temperature effects on paraben transport through silicone membranes
, 2013 This study investigates the effects of two surfactants (one anionic and one non-ionic) and controlled modifications in temperature (298–323 K) on the permeation of two structurally similar compounds through a silicone membrane using a Franz diffusion ...
Bibi, Aisha +3 more
core +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Relationship between Patterned Grounds Evolutions and Spatial and Temporal Changes in the Chemical Compounds of SAHL ABAD Playa Salt Flats (Case Study: Khorasan province) [PDF]
جغرافیا و پایداری محیط, 2019 The sensitive environment of Playa, as one of the largest mineral resources, has a special place in economic activities. Chemical compounds available in Playa are essential for soil which are used to fertilize agricultural soil.
Mahdi Saghafi
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source