Results 171 to 180 of about 954,955 (289)

Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma. [PDF]

Mol Ther Oncolytics, 2022
Spellerberg R, Benli-Hoppe T, Kitzberger C, Hageneier M, Schwenk N, Öztürk Ö, Steiger K, Multhoff G, Eiber M, Schilling F, Weber WA, Kälin RE, Glass R, Nelson PJ, Wagner E, Spitzweg C.   +15 more
europepmc   +1 more source

MOLECULAR-DYNAMICS SIMULATION OF THE CRYSTALLINE PHASE OF POLY(ETHYLENE OXIDE)-SODIUM IODIDE, PEO(3)NAI

, 1995
The polymer-polymer interaction potential used in an earlier reported MD simulation of crystalline PEO [Neyertz, Brown and Thomas, J. Chem. Phys., 101, 10064 (1994)] is here transferred to the crystalline phase of poly(ethylene oxide)-sodium iodide, PEO(
BROWN, D, NEYERTZ, S, Thomas, John,
core  

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source

The sodium/iodide symporter is a nitrate transporter in the human salivary gland. [PDF]

Redox Biol
Picozzi G, Westerberg LJS, Jurga J, Zeberg H, Nihlen C, Pernow J, Carlström M, Weitzberg E, Ågren R, Lundberg JO.   +9 more
europepmc   +1 more source

Basolateral Sorting of the Sodium/Iodide Symporter Is Mediated by Adaptor Protein 1 Clathrin Adaptor Complexes. [PDF]

Thyroid, 2022
Koumarianou P, Fernández-Méndez C, Fajardo-Delgado D, Mielu LM, Santisteban P, De la Vieja A.   +5 more
europepmc   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

Electron Donor–Acceptor Complex Catalysis in Synthetic Chemistry

Angewandte Chemie, EarlyView.
Electron donor–acceptor (EDA) complexes are moving beyond stoichiometric photoactivation toward catalytic platforms for radical generation. Productive EDA catalysis requires coordinated donor–acceptor association, charge‐transfer excitation, radical reactivity, and vcatalyst turnover.
Tristan von Münchow, Andrea Palone, Jonathan Samuel Trimble, Paolo Melchiorre   +3 more
wiley   +2 more sources

Interleukin-6-controlled, mesenchymal stem cell-based sodium/iodide symporter gene therapy improves survival of glioblastoma-bearing mice. [PDF]

Mol Ther Oncolytics, 2023
Kitzberger C, Shehzad K, Morath V, Spellerberg R, Ranke J, Steiger K, Kälin RE, Multhoff G, Eiber M, Schilling F, Glass R, Weber WA, Wagner E, Nelson PJ, Spitzweg C.   +14 more
europepmc   +1 more source

Development‐Informed Microsphere Assemblies Enable Spatiotemporally Programmed Bone–Vascular Organoid‐Like Constructs for Large Bone Defect Repair

Advanced Science, EarlyView.
Single‐cell‐guided prioritization of BMP4 and VEGFA is combined with temporally programmed BMSCs and a Matrigel‐free GelMA/PEO/bioactive‐glass assembled‐microsphere matrix to generate bone–vascular organoid‐like constructs. The platform coordinates osteogenic differentiation, endothelial activation, vascular‐like microchannel formation, and ...
Renhao Ni, Xinyi Shi, Tong Zhu, Guanrong Li, Lei Chang, Shengtao Li, Jingyi Chi, Chen Shi, Zeming Hu, Rong Xu, Yingchun Zhu, Yang Luo, Yichen Chen, Fan Yang, Yabin Zhu   +14 more
wiley   +1 more source

Supramolecular Enforcement of Planar Tetracoordinate Halides

Angewandte Chemie, EarlyView.
A calix[4]pyrrolato‐indium scaffold preorganizes Li4 pockets that trap Cl−, Br−, and I− in strongly flattened to square‐planar tetracoordinate environments. Computations reveal low planarization energies for the heavier halides, while crystallography shows that their geometry is readily modulated by subtle supramolecular and packing effects ...
Jie Zhang, Avijit Maiti, Lutz Greb
wiley   +2 more sources