Success of small-dose fractionated sodium thiosulfate in the treatment of calciphylaxis in a peritoneal dialysis patient [PDF]
BMC Nephrology, 2022 Background Calciphylaxis, or calcific uremic arteriolopathy (CUA), is a rare, fatal disorder of microvascular calcification and thrombosis that typically affects patients with end-stage renal disease (ESRD) receiving long-term dialysis.
Yuan Lu, Lei Shen, Ling Zhou, Deyu Xu
doaj +3 more sources
Photodegradation of Azathioprine in the Presence of Sodium Thiosulfate. [PDF]
Int J Mol Sci, 2022 The effect of sodium thiosulfate (ST) on the photodegradation of azathioprine (AZA) was analyzed by UV-VIS spectroscopy, photoluminescence (PL), FTIR spectroscopy, Raman scattering, X-ray photoelectron (XPS) spectroscopy, thermogravimetry (TG) and mass spectrometry (MS).
Toulbe N +5 more
europepmc +5 more sources
Clinical Efficacy and Safety of Sodium Thiosulfate in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials [PDF]
Toxins, 2021 Uremic pruritus is a distressful complication of chronic kidney disease and results in impaired quality of life and higher mortality rates. Intravenous sodium thiosulfate has been reported to alleviate pruritus in hemodialysis patients.
Ping-Hsun Lu +4 more
doaj +3 more sources
Biomimetic Grapefruit-Derived Extracellular Vesicles for Safe and Targeted Delivery of Sodium Thiosulfate against Vascular Calcification. [PDF]
ACS Nano, 2023 As the prevalence of vascular calcification (VC), a strong contributor to cardiovascular morbidity and mortality, continues to increase, the need for pharmacologic therapies becomes urgent.
Feng W +9 more
europepmc +2 more sources
Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization. [PDF]
Front Cardiovasc Med, 2022 Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis.
Macabrey D +11 more
europepmc +2 more sources
Cardioprotective effects of sodium thiosulfate against doxorubicin-induced cardiotoxicity in male rats. [PDF]
BMC Pharmacol Toxicol, 2022 Background Doxorubicin (DOX) is an effective antitumor agent, but its clinical usage is limited due to adverse cardiotoxic effects. Several compounds have been studied to reduce DOX cardiotoxicity to improve its therapeutic index. This study was aimed to
Shekari M +6 more
europepmc +2 more sources
Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease. [PDF]
Antioxidants (Basel), 2022 Hypertension is highly prevalent in chronic kidney disease (CKD). Hydrogen sulfide (H2S) is an endogenously produced gasotransmitter with vasodilator properties.
Hsu CN +5 more
europepmc +2 more sources
H2S in Critical Illness-A New Horizon for Sodium Thiosulfate? [PDF]
Biomolecules, 2022 Ever since the discovery of endogenous H2S and the identification of its cytoprotective properties, efforts have been made to develop strategies to use H2S as a therapeutic agent.
Merz T +6 more
europepmc +2 more sources
Sodium Thiosulfate: Pediatric First Approval
Pediatric Drugs, 2022 Sodium thiosulfate (Pedmark^®) is a chemoprotectant/antioxidant developed by Fennec Pharmaceuticals (formerly Adherex Technologies) to reduce to risk of hearing loss associated with cisplatin.
Sohita Dhillon
semanticscholar +3 more sources
Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms. [PDF]
Int J Mol Sci, 2021 Thiosulfate in the form of sodium thiosulfate (STS) is a major oxidation product of hydrogen sulfide (H2S), an endogenous signaling molecule and the third member of the gasotransmitter family.
Zhang MY +3 more
europepmc +2 more sources